The Oncosearch | Oncotarget

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Shiho Fukui, Kazunori Nagasaka, Yuko Miyagawa, Ryoko Kikuchi-Koike, Yoshiko Kawata, Ranka Kanda, Takayuki Ichinose, Takeru Sugihara, Haruko Hiraike, Osamu Wada-Hiraike, Yuko Sasajima, Takuya Ayabe

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5932-5948

Keywords: ovarian cancer, bAP15, TGF-β/Smad signaling, UCHL5, apoptosis

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Nikhil Gupta, Jung Eun Park, Wilford Tse, Jee Keem Low, Oi Lian Kon, Neil McCarthy, Siu Kwan Sze

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5970-5982

Keywords: pancreatic cancer, hypoxia tumor, ERO1α, SILAC, proteomics

Epigenetic silencing of HOPX is critically involved in aggressive phenotypes and patient prognosis in papillary thyroid cancer Research Paper

Yosuke Ooizumi, Hiroshi Katoh, Mitsuo Yokota, Masahiko Watanabe, Keishi Yamashita

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5906-5918

Keywords: HOPX, papillary thyroid cancer, epigenetic silencing, promoter methylation

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

Belen Alvarez-Palomo, Carme Barrot-Feixat, Helena Sarret, Jordi Requena, Montserrat Pau, Jose-Manuel Vidal-Taboada, Rafael Oliva, Josep-Lluis Ballesca, Michael J. Edel, Jovita Mezquita-Pla

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5871-5887

Keywords: ligand-independent intracellular iVEGFR-1 isoforms, mature testis, spermiogenesis, SRC activation, fertility

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Amanda M. Smith, Christine R.C. Zhang, Alexandre S. Cristino, John P. Grady, J. Lynn Fink, Andrew S. Moore

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5755-5767

Keywords: myeloid leukemia, therapy, drug resistance, hematological malignancies, gene mutation

Correction: POPX2 is a novel LATS phosphatase that regulates the Hippo pathway Correction

Muhammad Bakhait Rahmat, Songjing Zhang, Cheng-Gee Koh

Published Oct 3, 2019 · Vol. 10, No. 56 · pp. 5890-5891

Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone Research Paper

Balaji Krishnamachary, Dharmalingam Subramaniam, Prasad Dandawate, Sivapriya Ponnurangam, Pugazhendhi Srinivasan, Prabhu Ramamoorthy, Shahid Umar, Sufi Mary Thomas, Animesh Dhar, Seth Septer, Scott J. Weir, Thomas Attard, Shrikant Anant

Published Sep 24, 2019 · Vol. 10, No. 54 · pp. 5576-5591

Keywords: Wnt signaling, beta-catenin, natural product, tumor xenograft, preventive agent

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma Research Paper

Yuzan Kudo, Shiro Kohi, Keiji Hirata, Michael Goggins, Norihiro Sato

Published Sep 24, 2019 · Vol. 10, No. 54 · pp. 5592-5604

Keywords: hyaluronan, synthesis, degradation, pancreatic cancer, prognosis

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Kwang Woon Kim, Julia Y. Kim, Jingbo Qiao, Rachael A. Clark, Camille M. Powers, Hernan Correa, Dai H. Chung

Published Sep 24, 2019 · Vol. 10, No. 54 · pp. 5645-5659

Keywords: chemotherapy, radiotherapy, resistance, AKT2, MAPK

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

Jamie M. Aye, Laura L. Stafman, Adele P. Williams, Evan F. Garner, Jerry E. Stewart, Joshua C. Anderson, Smitha Mruthyunjayappa, Mary G. Waldrop, Caroline D. Goolsby, Hooper R. Markert, Colin Quinn, Raoud Marayati, Elizabeth Mroczek-Musulman, Christopher D. Willey, Karina J. Yoon, Kimberly F. Whelan, Elizabeth A. Beierle

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5534-5548

Keywords: kinase inhibition, Wilms tumor

Cathepsin L secretion by host and neoplastic cells potentiates invasion Research Paper

Samantha S. Dykes, Henrietta O. Fasanya, Dietmar W. Siemann

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5560-5568

Keywords: breast cancer, macrophage, invasion, cathepsin L

Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice Research Paper

Yuji Ueda, Koichi Kawamoto, Masamitsu Konno, Kozo Noguchi, Satoru Kaifuchi, Taroh Satoh, Hidetoshi Eguchi, Yuichiro Doki, Takaaki Hirotsu, Masaki Mori, Hideshi Ishii

Published Sep 10, 2019 · Vol. 10, No. 52 · pp. 5412-5418

Keywords: early detection, pancreatic cancer, C. elegans, genetically-engineered mice

SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells Research Paper

Ming-Bo Huang, Jennifer Y. Wu, James Lillard, Vincent C. Bond

Published Sep 10, 2019 · Vol. 10, No. 52 · pp. 5419-5438

Keywords: extracellular vesicles, mortalin, complement, SMR peptides, breast cancer

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Kwang Woon Kim, Julia Y. Kim, Jingbo Qiao, Rachael A. Clark, Camille M. Powers, Hernan Correa, Dai H. Chung

Published Sep 5, 2019

Keywords: chemotherapy, radiotherapy, resistance, AKT2, MAPK

SRC mediates cell cycle regulatory function of Pin1 and is a rational target in treating mucinous ovarian cancer Research Paper

Elisabeth Baron, Shubai Liu, Yuanyuan Hua, Junzheng Yang, Pui-Wah Choi, Wing-Chung Ng, Shu-Kay Ng, Jinyan Du, Charlene C. Ng, Xiao Zhen Zhou, Kun Ping Lu, William R. Welch, Christopher P. Crum, Ross S. Berkowitz, Shu-Wing Ng

Published Sep 3, 2019 · pp. 5724-5736

Keywords: cell cycle regulation, drug sensitivity, ovarian cancer, signal transduction, combination treatment

A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation Research Paper

Henning Karlsson, Wojciech Senkowski, Mårten Fryknäs, Sharmineh Mansoori, Stig Linder, Joachim Gullbo, Rolf Larsson, Peter Nygren

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5372-5382

Keywords: spheroid, tumor model, high-throughput, radiosensitizer, hypoxia

Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis Research Paper

Andrey V. Markov, Alexander E. Kel, Oksana V. Salomatina, Nariman F. Salakhutdinov, Marina A. Zenkova, Evgeniya B. Logashenko

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5267-5297

Keywords: soloxolone methyl, cervical carcinoma, CDDO-Me, cytoscape, mechanism of action

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

El-Habib Dakir, Faustino Mollinedo

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5313-5331

Keywords: miRNA, miR-125a-5p, miR-17-92, neutrophil differentiation, human

Cathepsin L secretion by host and neoplastic cells potentiates invasion Research Paper

Samantha S. Dykes, Henrietta O. Fasanya, Dietmar W. Siemann

Published Aug 27, 2019

Keywords: breast cancer, macrophage, invasion, cathepsin L

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper

Takeshi Jimbo, Mana Hatanaka, Takahiro Komatsu, Tomoe Taira, Kentaro Kumazawa, Naoyuki Maeda, Takashi Suzuki, Masahiro Ota, Noriyasu Haginoya, Takeshi Isoyama, Kosaku Fujiwara

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5152-5167

Keywords: AXL, DS-1205, EGFR-TKI resistance, erlotinib, osimertinib

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The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Epigenetic silencing of HOPX is critically involved in aggressive phenotypes and patient prognosis in papillary thyroid cancer Research Paper

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Correction: POPX2 is a novel LATS phosphatase that regulates the Hippo pathway Correction

Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone Research Paper

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma Research Paper

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

Cathepsin L secretion by host and neoplastic cells potentiates invasion Research Paper

Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice Research Paper

SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells Research Paper

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

SRC mediates cell cycle regulatory function of Pin1 and is a rational target in treating mucinous ovarian cancer Research Paper

A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation Research Paper

Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis Research Paper

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

Cathepsin L secretion by host and neoplastic cells potentiates invasion Research Paper

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Epigenetic silencing of HOPX is critically involved in aggressive phenotypes and patient prognosis in papillary thyroid cancer Research Paper

Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases Research Paper

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Correction: POPX2 is a novel LATS phosphatase that regulates the Hippo pathway Correction

Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone Research Paper

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma Research Paper

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

Cathepsin L secretion by host and neoplastic cells potentiates invasion Research Paper

Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice Research Paper

SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells Research Paper

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

SRC mediates cell cycle regulatory function of Pin1 and is a rational target in treating mucinous ovarian cancer Research Paper

A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation Research Paper

Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis Research Paper

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells Research Paper

Cathepsin L secretion by host and neoplastic cells potentiates invasion Research Paper

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper