The Oncosearch | Oncotarget

Hypoxia-inducible factors enhance glutamate signaling in cancer cells Priority Research Paper

Hongxia Hu, Naoharu Takano, Lisha Xiang, Daniele M. Gilkes, Weibo Luo, Gregg L. Semenza

Published Oct 15, 2014 · Vol. 5, No. 19 · pp. 8853-8868

miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma Research Paper

Ruifen Dong, Xiaolin Liu, Qing Zhang, Zhijun Jiang, Yingwei Li, Yuyan Wei, Yinuo Li, Qifeng Yang, Jinsong Liu, Jian-Jun Wei, Changshun Shao, Zhaojian Liu, Beihua Kong

Published Oct 14, 2014 · Vol. 5, No. 21 · pp. 10816-10829

Signaling pathways activation profiles make better markers of cancer than expression of individual genes Research Paper

Nikolay M. Borisov, Nadezhda V. Terekhanova, Alexander M. Aliper, Larisa S. Venkova, Philip Yu Smirnov, Sergey Roumiantsev, Mikhail B. Korzinkin, Alex A. Zhavoronkov, Anton A. Buzdin

Published Oct 13, 2014 · Vol. 5, No. 20 · pp. 10198-10205

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential Priority Research Paper

Philipp Raffeiner, Ruth RÃ¶ck, Andrea Schraffl, Markus Hartl, Jonathan R. Hart, Kim D. Janda, Peter K. Vogt, Eduard Stefan, Klaus Bister

Published Oct 12, 2014 · Vol. 5, No. 19 · pp. 8869-8878

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling Research Paper

Layka Abbasi Asbagh, Iria Vazquez, Loredana Vecchione, Eva Budinska, Veerle De Vriendt, Maria Francesca Baietti, Mikhail Steklov, Bart Jacobs, Nicholas Hoe, Sharat Singh, Naga-Sailaja Imjeti, Pascale Zimmermann, Anna Sablina, Sabine Tejpar

Published Oct 11, 2014 · Vol. 5, No. 20 · pp. 10070-10083

The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway Research Paper

Zaidoun Salah, Ella Itzhaki, Rami I. Aqeilan

Published Oct 11, 2014 · Vol. 5, No. 21 · pp. 10886-10900

Keywords: Key words: Hippo pathway, ITCH, YAP, breast cancer

Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells Research Paper

Sushil Kumar, Dileep Kumar, Komal Raina, Rajesh Agarwal, Chapla Agarwal

Published Oct 10, 2014 · Vol. 5, No. 20 · pp. 10151-10169

Keywords: colorectal cancer, obesity, chemoprevention, phytochemicals, adipocytes

Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients Clinical Research Papers

Corinna Eichelser, Isabel StÃ¼ckrath, Volkmar MÃ¼ller, Karin Milde-Langosch, Harriet Wikman, Klaus Pantel, Heidi Schwarzenbach

Published Oct 7, 2014 · Vol. 5, No. 20 · pp. 9650-9663

AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients Research Paper

Benoit Langlois, Falk Saupe, Tristan Rupp, Christiane Arnold, MichaÃ«l Van der Heyden, Gertraud Orend, Thomas Hussenet

Published Oct 7, 2014 · Vol. 5, No. 21 · pp. 10529-10545

Keywords: Tumor angiogenesis, angiogenic switch, extracellular matrix, matrisome

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-ÎºB pathways Research Paper

Chunlin Zhuang, Chunquan Sheng, Woo Shik Shin, Yuelin Wu, Jin Li, Jianzhong Yao, Guoqiang Dong, Wen Zhang, Yuk Yin Sham, Zhenyuan Miao, Wannian Zhang

Published Oct 7, 2014 · Vol. 5, No. 21 · pp. 10830-10839

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway Research Paper

Hongyu Zhou, Tao Shen, Chaowei Shang, Yan Luo, Lei Liu, Juming Yan, Yan Li, Shile Huang

Published Oct 4, 2014 · Vol. 5, No. 20 · pp. 10140-10150

Keywords: Ciclopirox, autophagy, rhabdomyosarcoma, reactive oxygen species, JNK

The nuclear import of ribosomal proteins is regulated by mTOR Priority Research Paper

Dubek Kazyken, Yelimbek Kaz, Vladimir Kiyan, Assylbek A. Zhylkibayev, Chien-Hung Chen, Nitin K. Agarwal, Dos D. Sarbassov

Published Oct 3, 2014 · Vol. 5, No. 20 · pp. 9577-9593

Keywords: mTOR (mechanistic target of rapamycin), kinase, ribosomal proteins, nuclear import

Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer Review

Ehsan Malek, Sajjeev Jagannathan, James J. Driscoll

Published Sep 29, 2014 · Vol. 5, No. 18 · pp. 8027-8038

Keywords: non-coding RNAs, long-non-coding RNAs, microRNAs, HOTAIR, overall survival

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib Research Paper

Mohamad Younes, Zherui Wu, Sandra Dupouy, Audrey Mansuet Lupo, Najat Mourra, Takashi Takahashi, Jean-Francois Flejou, Jean TrÃ©daniel, Jean FranÃ§ois RÃ©gnard, Diane Damotte, Marco Alifano, Patricia Forgez

Published Sep 26, 2014 · Vol. 5, No. 18 · pp. 8252-8269

Keywords: Cancer growth and metastasis, neurotensin, EGFR, HER2, HER3, EGF like ligands.

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells Research Paper

Lymor Ringer, Paul Sirajuddin, Lucas Tricoli, Sarah Waye, Muhammad Umer Choudhry, Erika Parasido, Angiela Sivakumar, Mary Heckler, Aisha Naeem, Iman Abdelgawad, Xuefeng Liu, Adam S. Feldman, Richard J. Lee, Chin-Lee Wu, Venkata Yenugonda, Bhaskar Kallakury, Anatoly Dritschilo, John Lynch, Richard Schlegel, Olga Rodriguez, Richard G. Pestell, Maria Laura Avantaggiati, Chris Albanese

Published Sep 26, 2014 · Vol. 5, No. 21 · pp. 10678-10691

Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1 Priority Research Paper

Verena Wagner, Dirk Hose, Anja Seckinger, Ludmila Weiz, Tobias MeiÃŸner, Thiery RÃ¨me, Iris Breitkreutz, Klaus Podar, Anthony D. Ho, Hartmut Goldschmidt, Alwin KrÃ¤mer, Bernard Klein, Marc S. Raab

Published Sep 26, 2014 · Vol. 5, No. 21 · pp. 10237-10250

Pharmacological targeting the ATRâ€“CHK1â€“WEE1 axis involves balancing cell growth stimulation and apoptosis Research Paper

Joyce P.Y. Mak, Wing Yu Man, Hoi Tang Ma, Randy Y.C. Poon

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10546-10557

MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis Research Paper

Katia Danza, Simona De Summa, Rosamaria Pinto, Brunella Pilato, Orazio Palumbo, Giuseppe Merla, Gianni Simone, Stefania Tommasi

Published Sep 25, 2014 · Vol. 6, No. 1 · pp. 471-483

De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells Research Paper

Yi-Wen Chang, Hsin-An Chen, Chi-Feng Tseng, Chih-Chen Hong, Jui-Ti Ma, Mien-Chie Hung, Chih-Hsiung Wu, Ming-Te Huang, Jen-Liang Su

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10558-10570

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling Clinical Research Papers

Tao Wang, Shuiming Guo, Zhuo Liu, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen, Xiaming Liu, Hua Xu, Shaoxin Cai, Hui Chen, Weiyong Li, Shaohua Xu, Liang Wang, Zhiquan Hu, Qianyuan Zhuang, Liping Wang, Kongming Wu, Jihong Liu, Zhangqun Ye, Jun-Yuan Ji, Chenguang Wang, Ke Chen

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10293-10306

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Hypoxia-inducible factors enhance glutamate signaling in cancer cells Priority Research Paper

miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma Research Paper

Signaling pathways activation profiles make better markers of cancer than expression of individual genes Research Paper

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential Priority Research Paper

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling Research Paper

The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway Research Paper

Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells Research Paper

Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients Clinical Research Papers

AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients Research Paper

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-ÎºB pathways Research Paper

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway Research Paper

The nuclear import of ribosomal proteins is regulated by mTOR Priority Research Paper

Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer Review

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib Research Paper

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells Research Paper

Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1 Priority Research Paper

Pharmacological targeting the ATRâ€“CHK1â€“WEE1 axis involves balancing cell growth stimulation and apoptosis Research Paper

MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis Research Paper

De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells Research Paper

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling Clinical Research Papers

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Hypoxia-inducible factors enhance glutamate signaling in cancer cells Priority Research Paper

miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma Research Paper

Signaling pathways activation profiles make better markers of cancer than expression of individual genes Research Paper

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential Priority Research Paper

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling Research Paper

The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway Research Paper

Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells Research Paper

Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients Clinical Research Papers

AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients Research Paper

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-ÎºB pathways Research Paper

Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway Research Paper

The nuclear import of ribosomal proteins is regulated by mTOR Priority Research Paper

Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer Review

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib Research Paper

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells Research Paper

Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1 Priority Research Paper

Pharmacological targeting the ATRâ€“CHK1â€“WEE1 axis involves balancing cell growth stimulation and apoptosis Research Paper

MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis Research Paper

De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells Research Paper

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling Clinical Research Papers