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Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

MickaÃ«l Ohanna, Yann Cheli, Caroline Bonet, Vanessa F Bonazzi, Marylin Allegra, Sandy Giuliano, Karine Bille, Philippe Bahadoran, Damien Giacchero, Jean Philippe Lacour, Glen M Boyle, Nicholas F Hayward, Corine Bertolotto, Robert Ballotti

Published Aug 19, 2013 · Vol. 4, No. 12 · pp. 2212-2224

Keywords: melanoma, senescence, secretome, STAT3

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

Ryan T Pitman, Luke Wojdyla, Neelu Puri

Published Jun 3, 2013 · Vol. 4, No. 5 · pp. 761-771

Keywords: T-oligo, Tankyrase, TRF1, telomere, p53, melanoma

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

Yaoyu Chen, Jinyun Chen, Alice Loo, Savina Jaeger, Linda Bagdasarian, Jianjun Yu, Franklin Chung, Joshua Korn, David Ruddy, Ribo Guo, Margaret Mclaughlin, Fei Feng, Ping Zhu, Frank Stegmeier, Raymond Pagliarini, Dale Porter, Wenlai Zhou

Published Apr 23, 2013 · Vol. 4, No. 6 · pp. 816-829

Keywords: HSF1, cancer cells, HSP90 inhibitor, Melanoma, HCC, DEDD2

NRAS mutant melanoma â€“ undrugable? Broadcast

Christian Posch, Susana Ortiz-Urda

Published Apr 13, 2013 · Vol. 4, No. 4 · pp. 494-495

Keywords: NRAS, treatment, pathway inhibition

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Arnaldur Hall, Kathrine Damm Meyle, Marina Krarup Lange, Martin Klima, May Sanderhoff, Christina Dahl, Cecilie Abildgaard, Katrine Thorup, Seyed Moein Moghimi, Per Bo Jensen, Jiri Bartek, Per Guldberg, Claus Christensen

Published Apr 8, 2013 · Vol. 4, No. 4 · pp. 584-599

Keywords: Oncogene addiction, melanoma, V600EBRAF, the Warburg effect, glycolysis, oxidative phosphorylation

Effects of CT-Xp Gene Knock down in Melanoma Cell Lines Research Paper

Otavia Luisa Caballero, Tzeela Cohen, Sita Gurung, Ramon Chua, Peishan Lee, Yao-Tseng Chen, Parmjit Jat, Lloyd J. Old, Andrew J. G. Simpson

Published Mar 27, 2013 · Vol. 4, No. 4 · pp. 531-541

Keywords: Cancer/testis genes, GAGE, XAGE1, SSX, siRNA, melanoma

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

Meiyun Fan, Susan R. Pfeffer, Henry T. Lynch, Pamela Cassidy, Sancy Leachman, Lawrence M. Pfeffer, Levy Kopelovich

Published Jan 19, 2013 · Vol. 4, No. 1 · pp. 128-141

Keywords: Familial Melanoma, gene expression, CDKN2A, p16, Mutations, Melanoma

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Guillaume Robert, ValÃ©rie Jullian, Arnaud Jacquel, ClÃ©mence Ginet, Maeva Dufies, Stephanie Torino, AnaÃ¯s Pottier, Frederic Peyrade, Sophie Tartare-Deckert, GeneviÃ¨ve Bourdy, Eric Deharo, Patrick Auberger

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1688-1699

Keywords: Simalikalactone E, B-Raf inhibitor, CML, Melanoma, Hairy Cell Leukemia, ERK pathway

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma Research Paper

Irfan A Asangani, Paul W Harms, Lois Dodson, Mithil Pandhi, Lakshmi P Kunju, Christopher A Maher, Douglas R Fullen, Timothy M Johnson, Thomas J Giordano, Nallasivam Palanisamy, Arul M Chinnaiyan

Published Aug 31, 2012 · Vol. 3, No. 9 · pp. 1011-1025

Keywords: microRNA-31, melanoma, tumor suppressor, EZH2, DZNep

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Valentina Bevelacqua, Ylenia Bevelacqua, Saverio Candido, Evangelica Skarmoutsou, Alfredo Amoroso, Claudio Guarneri, Angela Strazzanti, Pietro Gangemi, Maria Clorinda Mazzarino, Fabio D'Amico, James A McCubrey, Massimo Libra, Grazia Malaponte

Published Aug 26, 2012 · Vol. 3, No. 8 · pp. 882-892

Keywords: NECL-5, melanoma, nevus, skin

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

Limo Chen, Bertal H Aktas, Yibo wang, Xiaoying He, Rupam Sahoo, Nancy Zhang, Severine Denoyelle, Eihab Kabha, Hongwei Yang, Revital Yefidoff Freedman, Jeffrey G. Supko, Michael Chorev, Gerhard Wagner, Jose A. Halperin

Published Aug 25, 2012 · Vol. 3, No. 8 · pp. 869-881

Keywords: translation initiation, eIF4F, eIF4E, eIF2a, eIF4G

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Ruchi Singhal, Eugene S. Kandel

Published Jul 31, 2012 · Vol. 3, No. 7 · pp. 700-708

Keywords: IPA3, PAK1, BRAF, NRAS, KRAS, melanoma, colon cancer, GDC-0879, AZD6244

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Veronique Mathieu, Christine Pirker, Wolfgang M Schmidt, Sabine Spiegl-Kreinecker, Daniela LÃ¶tsch, Petra Heffeter, Balazs Hegedus, Michael Grusch, Robert Kiss, Walter Berger

Published Apr 24, 2012 · Vol. 3, No. 4 · pp. 399-413

Keywords: malignant melanoma, aneuploidy, xenograft, aggressiveness, integrative genomics

The Expression of p-STAT3 in Stage IV Melanoma: Risk of CNS Metastasis and Survival Research Paper

Ian Lee, Patricia S. Fox, Sherise D. Ferguson, Roland L. Bassett, Jr., Ling-Yuan Kong, Christopher W. Schacherer, Jeffrey E. Gershenwald, Elizabeth A. Grimm, Gregory N. Fuller, Amy B. Heimberger

Published Apr 6, 2012 · Vol. 3, No. 3 · pp. 336-344

Keywords: melanoma, p-STAT3, CNS metastasis, prognosis

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Max Schlaak, Patrick Schmidt, Christopher Bangard, Peter Kurschat, Cornelia Mauch, Hinrich Abken

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 22-30

Keywords: cancer stem cell, melanoma, CD20, rituximab

Galectin-1 as an oncotarget in gliomas and melanomas Editorial Comments

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 892-893

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects Research Paper

Taolin Yi, Paul Elson, Masato Mitsuhashi, Barbara Jacobs, Emese Hollovary, G. Thomas Budd, Timothy Spiro, Pierre Triozzi, Ernest Borden

Published Dec 22, 2011 · Vol. 2, No. 12 · pp. 1155-1164

New Perspectives on the Role of Vitiligo in Immune Responses to Melanoma Research Perspective

Katelyn T. Byrne, Mary Jo Turk

Published Sep 10, 2011 · Vol. 2, No. 9 · pp. 684-694

Keywords: melanoma, vitiligo, melanocytes, CD8 T cells, CD4 T cells, T cell memory

NUAK2: an emerging acral melanoma oncogene Research Perspective

Takeshi Namiki, Sergio G. Coelho, Vincent J. Hearing

Published Sep 10, 2011 · Vol. 2, No. 9 · pp. 695-704

Keywords: NUAK2, acral melanoma, migration, metastasis, oncogene

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective

Ryan B. Corcoran, Jeffrey Settleman, Jeffrey A. Engelman

Published Apr 19, 2011 · Vol. 2, No. 4 · pp. 336-346

Keywords: BRAF, MEK, acquired resistance, melanoma, colorectal cancer, NRAS, IGF1R, PDGFR

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Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

NRAS mutant melanoma â€“ undrugable? Broadcast

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Effects of CT-Xp Gene Knock down in Melanoma Cell Lines Research Paper

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma Research Paper

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

The Expression of p-STAT3 in Stage IV Melanoma: Risk of CNS Metastasis and Survival Research Paper

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Galectin-1 as an oncotarget in gliomas and melanomas Editorial Comments

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects Research Paper

New Perspectives on the Role of Vitiligo in Immune Responses to Melanoma Research Perspective

NUAK2: an emerging acral melanoma oncogene Research Perspective

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype. Research Paper

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

NRAS mutant melanoma â€“ undrugable? Broadcast

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene Research Paper

Effects of CT-Xp Gene Knock down in Melanoma Cell Lines Research Paper

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway Research Paper

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma Research Paper

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

The Expression of p-STAT3 in Stage IV Melanoma: Risk of CNS Metastasis and Survival Research Paper

Regression of metastatic melanoma by targeting cancer stem cells Brief Reports

Galectin-1 as an oncotarget in gliomas and melanomas Editorial Comments

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects Research Paper

New Perspectives on the Role of Vitiligo in Immune Responses to Melanoma Research Perspective

NUAK2: an emerging acral melanoma oncogene Research Perspective

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers Research Perspective