The Oncosearch | Oncotarget

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition. Research Paper

Pooja Mohan, Joan Castellsague, Jihong Jiang, Kristi Allen, Helen Chen, Oksana Nemirovsky, Melanie Spyra, Kaiji Hu, Lan Kluwe, Miguel Angel Pujana, Alberto Villanueva, Victor F. Mautner, Jonathan J. Keats, Sandra E. Dunn, Conxi Lazaro, Christopher A. Maxwell

Published Jan 9, 2013 · Vol. 4, No. 1 · pp. 80-93

Keywords: Malignant peripheral nerve sheath tumors, Aurora kinase A, RHAMM, TPX2, cancer stem cell

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Laura Lehtinen, Kirsi Ketola, Rami MÃ¤kelÃ¤, John-Patrick Mpindi, Miro Viitala, Olli Kallioniemi, Kristiina Iljin

Published Dec 17, 2012 · Vol. 4, No. 1 · pp. 48-63

Keywords: Breast cancer, vimentin, MTHFD2

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

Naohito Kobayashi, Hiroji Uemura, Kiyotaka Nagahama, Koji Okudela, Mitsuko Furuya, Yoko Ino, Yusuke Ito, Hisashi Hirano, Yoshiaki Inayama, Ichiro Aoki, Yoji Nagashima, Yoshinobu Kubota, Hitoshi Ishiguro

Published Nov 17, 2012 · Vol. 3, No. 11 · pp. 1455-1471

Keywords: miRNA-30d, prostate cancer, biochemical recurrence, SOCS1

FAK is a critical regulator of neuroblastoma liver metastasis Research Paper

Sora Lee, Jingbo Qiao, Pritha Paul, Kathleen L. Oâ€™Connor, Mark Evers, Dai H. Chung

Published Nov 16, 2012 · Vol. 3, No. 12 · pp. 1576-1587

Keywords: GRP-R, FAK, malignant transformation, metastasis, neuroblastoma

Residual malignant and normal plasma cells shortly after high dose melphalan and stem cell transplantation. Highlight of a putative therapeutic window in Multiple Myeloma? Research Paper

Anouk Caraux, Laure Vincent, Salahedine Bouhya, Philippe Quittet, JÃ©rÃ´me Moreaux, Guilhem Requirand, Jean-Luc Veyrune, GaÃ«lle Olivier, Guillaume Cartron, Jean-FranÃ§ois Rossi, Bernard Klein

Published Oct 25, 2012 · Vol. 3, No. 11 · pp. 1335-1347

Keywords: Multiple Myeloma, Plasma cells, Minimal residual disease, Human

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Robert Callahan, Uma Mudunuri, Sharon Bargo, Ahmed Raafat, David McCurdy, Corinne Boulanger, William Lowther, Robert Stephens, Brian T. Luke, Claudia Stewart, Xiaolin Wu, David Munroe, Gilbert H. Smith

Published Oct 17, 2012 · Vol. 3, No. 11 · pp. 1320-1334

Keywords: mouse mammary tumor virus, premalignant lesions, mammary tumors, genes, human breast carcinomas, metastases

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Kasthuri Kannan, Akiko Inagaki, Joachim Silber, Daniel Gorovets, Jianan Zhang, Edward R. Kastenhuber, Adriana Heguy, John H. Petrini, Timothy A. Chan, Jason T. Huse

Published Oct 11, 2012 · Vol. 3, No. 10 · pp. 1194-1203

Keywords: glioma, astrocytoma, IDH, ATRX, whole-exome sequencing

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Lydia Kriegl, Michael Vieth, Thomas Kirchner, Antje Menssen

Published Oct 3, 2012 · Vol. 3, No. 10 · pp. 1182-1193

Keywords: Serrated route, colorectal cancer, SIRT1, c-MYC, BRAF and KRAS mutation, wnt signalling

Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin Research Paper

Jantine Posthuma De Boer, Pim W. van Egmond, Marco N. Helder, RenÃ©e X. de Menezes, Anne-Marie Cleton-Jansen, Jeroen A.M. BeliÃ«n, Henk M.W. Verheul, Barend J. van Royen, Gert-Jan J.L. Kaspers, Victor W. van Beusechem

Published Sep 28, 2012 · Vol. 3, No. 10 · pp. 1169-1181

Keywords: osteosarcoma, functional genomics, siRNA, chemosensitisation, JIP1

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma Research Paper

John de Groot, Ji Liang, Ling-Yuan Kong, Jun Wei, Yuji Piao, Gregory Fuller, Wei Qiao, Amy B Heimberger

Published Sep 19, 2012 · Vol. 3, No. 9 · pp. 1036-1048

Keywords: bevacizumab, anti-vascular endothelial growth factor, signal transducer and activator of transcription 3, treatment failure, invasion

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Valentina Bevelacqua, Ylenia Bevelacqua, Saverio Candido, Evangelica Skarmoutsou, Alfredo Amoroso, Claudio Guarneri, Angela Strazzanti, Pietro Gangemi, Maria Clorinda Mazzarino, Fabio D'Amico, James A McCubrey, Massimo Libra, Grazia Malaponte

Published Aug 26, 2012 · Vol. 3, No. 8 · pp. 882-892

Keywords: NECL-5, melanoma, nevus, skin

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

Limo Chen, Bertal H Aktas, Yibo wang, Xiaoying He, Rupam Sahoo, Nancy Zhang, Severine Denoyelle, Eihab Kabha, Hongwei Yang, Revital Yefidoff Freedman, Jeffrey G. Supko, Michael Chorev, Gerhard Wagner, Jose A. Halperin

Published Aug 25, 2012 · Vol. 3, No. 8 · pp. 869-881

Keywords: translation initiation, eIF4F, eIF4E, eIF2a, eIF4G

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Daniela Bressanin, Camilla Evangelisti, Francesca Ricci, Giovanna Tabellini, Francesca Chiarini, Pier Luigi Tazzari, Fraia Melchionda, Francesca Buontempo, Pasqualepaolo Pagliaro, Andrea Pession, James A McCubrey, Alberto M. Martelli

Published Aug 9, 2012 · Vol. 3, No. 8 · pp. 811-823

Keywords: acute leukemia, targeted therapy, signal transduction modulators, PI3K/PDK1, vertical inhibition

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas Research Paper

Yuchen Jiao, Patrick J. Killela, Zachary J. Reitman, B.Ahmed Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, Sergio Rosemberg, Sueli Meiko Obashinjo, Suely Kazue Nagahashi Marie, Chetan Bettegowda, Nishant Agrawal, Eric Lipp, Christopher Pirozzi, Giselle Lopez, Yiping He, Henry Friedman, Allan H. Friedman, Gregory J. Riggins, Matthias Holdhoff, Peter Burger, Roger McLendon, Darell D. Bigner, Bert Vogelstein, Alan K. Meeker, Kenneth W. Kinzler, Nickolas Papadopoulos, Luis A. Diaz, Jr., Hai Yan

Published Aug 3, 2012 · Vol. 3, No. 7 · pp. 709-722

Keywords: ALT, IDH1, IDH2, Mixed Gliomas

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma. Brief Reports

Katsuhiro Uzawa, Takao Baba, Fumihiko Uchida, Masanobu Yamatoji, Atsushi Kasamatsu, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hiroki Bukawa, Hideki Tanzawa

Published Jul 25, 2012 · Vol. 3, No. 7 · pp. 670-677

Keywords: squamous cell carcinoma, mitochondrial DNA, high-resolution melting curve analysis, circulating tumor-derived DNA, prognosis

Voltage-dependent K+ channels as oncotargets in malignant gliomas Editorial Comments

Florence Lefranc, Henri-Benjamin Pouleau, Michal Rynkowski, Olivier De Witte

Published Jun 1, 2012 · Vol. 3, No. 5 · pp. 516-517

Novel Therapeutic Targets in the Brain Tumor Microenvironment Research Perspective

Joanna J. Phillips

Published May 25, 2012 · Vol. 3, No. 5 · pp. 568-575

Mantle cell lymphoma-like lymphomas in c-myc-3â€™RR/p53+/- mice and c-myc-3â€™RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin Methodological Reports

Published May 9, 2012 · Vol. 3, No. 5 · pp. 586-593

Keywords: Mantle cell lymphomas, c-myc, p53, Cdk4, transgenic mice

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper

Yin Ye, Yi Xiao, Wenting Wang, Jian-Xin Gao, Kurtis Yearsley, Quintao Yan, Sanford H. Barsky

Published May 9, 2012 · Vol. 3, No. 4 · pp. 475-489

Keywords: SNF2LT, chromatin remodelling ATPase, cell cycle checkpoints

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Veronique Mathieu, Christine Pirker, Wolfgang M Schmidt, Sabine Spiegl-Kreinecker, Daniela LÃ¶tsch, Petra Heffeter, Balazs Hegedus, Michael Grusch, Robert Kiss, Walter Berger

Published Apr 24, 2012 · Vol. 3, No. 4 · pp. 399-413

Keywords: malignant melanoma, aneuploidy, xenograft, aggressiveness, integrative genomics

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Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition. Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

FAK is a critical regulator of neuroblastoma liver metastasis Research Paper

Residual malignant and normal plasma cells shortly after high dose melphalan and stem cell transplantation. Highlight of a putative therapeutic window in Multiple Myeloma? Research Paper

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin Research Paper

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma Research Paper

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas Research Paper

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma. Brief Reports

Voltage-dependent K+ channels as oncotargets in malignant gliomas Editorial Comments

Novel Therapeutic Targets in the Brain Tumor Microenvironment Research Perspective

Mantle cell lymphoma-like lymphomas in c-myc-3â€™RR/p53+/- mice and c-myc-3â€™RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin Methodological Reports

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition. Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

FAK is a critical regulator of neuroblastoma liver metastasis Research Paper

Residual malignant and normal plasma cells shortly after high dose melphalan and stem cell transplantation. Highlight of a putative therapeutic window in Multiple Myeloma? Research Paper

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin Research Paper

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma Research Paper

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Tumor suppression by small molecule inhibitors of translation initiation Research Paper

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas Research Paper

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma. Brief Reports

Voltage-dependent K+ channels as oncotargets in malignant gliomas Editorial Comments

Novel Therapeutic Targets in the Brain Tumor Microenvironment Research Perspective

Mantle cell lymphoma-like lymphomas in c-myc-3â€™RR/p53+/- mice and c-myc-3â€™RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin Methodological Reports

Singular v Dual Inhibition of SNF2L and Its Isoform, SNF2LT, Have Similar Effects on DNA Damage but Opposite Effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis Research Paper

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation Research Paper