The Oncosearch | Oncotarget

Genetic modifiers of p53: opportunities for breast cancer therapies Editorial Perspective

Prabin Dhangada Majhi, Aman Sharma, D. Joseph Jerry

Published Mar 11, 2023 · Vol. 14, No. 1 · pp. 236-241

Keywords: p53, Li-Fraumeni syndrome, genetic modifiers, breast cancer, DNA repair

Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells Review

Mikhail V. Blagosklonny

Published Mar 3, 2023 · Vol. 14, No. 1 · pp. 193-206

Keywords: oncology, resistance, cyclotherapy, trilaciclib, rapamycin

Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss Research Paper

Maroun Bou Zerdan, Prashanth Ashok Kumar, Elio Haroun, Nimisha Srivastava, Jeffrey Ross, Abirami Sivapiragasam

Published Feb 25, 2023 · Vol. 14, No. 1 · pp. 178-187

Keywords: breast cancer, metastatic, MTAP loss

Calcium signaling induced by 15-deoxy-prostamide-J₂ promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore Research Paper

Daniel A. Ladin, Margaret M. Nelson, Estefani Cota, Catherine Colonna, Colin Burns, Jacques Robidoux, Kelsey H. Fisher-Wellman, Rukiyah Van Dross-Anderson

Published Dec 14, 2022 · Vol. 13, No. 1 · pp. 1380-1396

Keywords: calcium, mitochondrial respiration, endoplasmic reticulum stress, cancer, prostamide

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Hirofumi Tsuzuki, Tatsuya Kawase, Taisuke Nakazawa, Masamichi Mori, Taku Yoshida

Published Dec 13, 2022 · Vol. 13, No. 1 · pp. 1359-1368

Keywords: acute myeloid leukemia (AML), ASP1235, antibody drug conjugate (ADC), venetoclax, azacitidine

Therapeutic efficacy of the humanized JAA-F11 anti-Thomsen-Friedenreich antibody constructs H2aL2a and H3L3 in human breast and lung cancer xenograft models Research Paper

Diala Ghazal, Fatma Zalzala, John C. Fisk, Swetha Tati, Loukia G. Karacosta, Susan Morey, James R. Olson, Sally Quataert, Grace K. Dy, Kate Rittenhouse-Olson

Published Oct 7, 2022 · Vol. 13, No. 1 · pp. 1155-1164

Keywords: hJAA-F11, TF-Ag, Thomsen-Friedenreich antigen, tumor immunotherapy, translational oncology

Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival Research Paper

Jude B. Khatib, Emily M. Schleicher, Lindsey M. Jackson, Ashna Dhoonmoon, George-Lucian Moldovan, Claudia M. Nicolae

Published Sep 23, 2022 · Vol. 13, No. 1 · pp. 1078-1091

Keywords: PARP10, ATM, CRISPR screens, genome stability, cancer cell proliferation

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

Daiki Ueno, Juan C. Vasquez, Amrita Sule, Jiayu Liang, Jinny van Doorn, Ranjini Sundaram, Sam Friedman, Randy Caliliw, Shinji Ohtake, Xun Bao, Jing Li, Huihui Ye, Karla Boyd, Rong Rong Huang, Jack Dodson, Paul Boutros, Ranjit S. Bindra, Brian Shuch

Published Sep 3, 2022 · Vol. 13, No. 1 · pp. 1054-1067

Keywords: FH, SDHB, renal cell carcinoma, PARP inhibitor, temozolomide

Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma Research Paper

Francis R. LeBlanc, Zainul S. Hasanali, August Stuart, Sara Shimko, Kamal Sharma, Violetta V. Leshchenko, Samir Parekh, Haiqing Fu, Ya Zhang, Melvenia M. Martin, Mark Kester, Todd Fox, Jiangang Liao, Thomas P. Loughran, Juanita Evans, Jeffrey J. Pu, Stephen E. Spurgeon, Mirit I. Aladjem, Elliot M. Epner

Published Jul 9, 2022 · Vol. 13, No. 1 · pp. 986-1002

Keywords: epigenetics, blastic mantle cell lymphoma, cladribine

Targeting lipid metabolism in the treatment of ovarian cancer Review

Saliha Chaudhry, Stefani N. Thomas, Glenn E. Simmons Jr.

Published May 18, 2022 · Vol. 13, No. 1 · pp. 768-783

Keywords: ovarian cancer, lipid metabolism, biomarkers, microenvironment, fatty acid

Role of the prorenin receptor in endometrial cancer cell growth Research Paper

Jacinta H. Martin, Riazuddin Mohammed, Sarah J. Delforce, David A. Skerrett-Byrne, Celine Corbisier de Meaultsart, Juhura G. Almazi, Andrew N. Stephens, Nicole M. Verrills, Evdokia Dimitriadis, Yu Wang, Eugenie R. Lumbers, Kirsty G. Pringle

Published Mar 23, 2022 · Vol. 13, No. 1 · pp. 587-599

Keywords: (P)RR, ATP6AP2, endometrial cancer, cellular viability, cellular proliferation

Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma Case Report

Eugene J. Vaios, Kristen A. Batich, Anne F. Buckley, Anastasie Dunn-Pirio, Mallika P. Patel, John P. Kirkpatrick, Ranjit Goudar, Katherine B. Peters

Published Mar 15, 2022 · Vol. 13, No. 1 · pp. 576-582

Keywords: radiation necrosis, brain tumor, primary CNS lymphoma, stereotactic radiosurgery, bevacizumab

Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients Research Paper

Eric R. Molina, Letitia K. Chim, Salah-Eddine Lamhamedi-Cherradi, Sana Mohiuddin, David McCall, Branko Cuglievan, Sandhya Krishnan, Robert W. Porter, Davis R. Ingram, Wei-Lien Wang, Alexander J. Lazar, David W. Scott, Danh D. Truong, Najat C. Daw, Joseph A. Ludwig, Antonios G. Mikos

Published Mar 1, 2022 · Vol. 13, No. 1 · pp. 521-533

Keywords: osteosarcoma, YAP/TAZ, IGF-1R, nuclear IGF-1R, mechanotransduction

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity Research Paper

Daniel Menendez, Jay R. Anand, Carri C. Murphy, Whitney J. Bell, Jiaqi Fu, Nadia Slepushkina, Eugen Buehler, Scott E. Martin, Madhu Lal-Nag, John L. Nitiss, Michael A. Resnick

Published Feb 4, 2022 · Vol. 13, No. 1 · pp. 332-346

Keywords: tumor suppressor, siRNA screen, synthetic lethality, ICE assay, Top2 covalent complexes

Correction: Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1 Correction

Jingyuan Li, Tongshuai Chen, Ming Xiao, Na Li, Shujian Wang, Hongyan Su, Xiaobin Guo, Hui Liu, Fangying Yan, Yi Yang, Yun Zhang, Peili Bu

Published Dec 1, 2021 · Vol. 13, No. 1 · pp. 723-724

Correction: LncRNA CHRF-induced miR-489 loss promotes metastasis of colorectal cancer via TWIST1/EMT signaling pathway Correction

Youmao Tao, Tao Han, Tao Zhang, Chong Ma, Caixia Sun

Published Nov 5, 2021

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Lara H. El Touny, Curtis Hose, John Connelly, Erik Harris, Anne Monks, Angie B. Dull, Deborah F. Wilsker, Melinda G. Hollingshead, Michelle Gottholm-Ahalt, Sergio Y. Alcoser, Michael E. Mullendore, Ralph E. Parchment, James H. Doroshow, Beverly A. Teicher, Annamaria Rapisarda

Published Sep 28, 2021 · Vol. 12, No. 21 · pp. 2114-2130

Keywords: TMZ, MMR, ATR, HR, REV3L

Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis Research Paper

Jessica I. Christian, Agnieszka Pastula, Andreas Herbst, Jens Neumann, Maximilian K. Marschall, Andrea Ofner, Heike Zierahn, Marlon R. Schneider, Eckhard Wolf, Michael Quante, Frank T. Kolligs

Published Sep 22, 2021 · Vol. 13, No. 1 · pp. 615-627

Keywords: DRO1, CCDC80, colorectal cancer, tumor microenvironment, tumor suppressor

Control of the Mdm2-p53 signal loop by β-arrestin 2: The ins and outs Editorial

Elodie Blondel-Tepaz, Hervé Enslen, Mark G.H. Scott

Published Aug 24, 2021 · Vol. 12, No. 26 · pp. 2543-2545

Keywords: β-arrestin, Mdm2, p53, RanGAP1, SUMO

Anti-aging: senolytics or gerostatics (unconventional view) Review

Mikhail V. Blagosklonny

Published Aug 12, 2021 · Vol. 12, No. 18 · pp. 1821-1835

Keywords: geroscience, senolytics, hyperfunction theory, aging, sirolimus

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Genetic modifiers of p53: opportunities for breast cancer therapies Editorial Perspective

Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells Review

Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss Research Paper

Calcium signaling induced by 15-deoxy-prostamide-J₂ promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore Research Paper

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Therapeutic efficacy of the humanized JAA-F11 anti-Thomsen-Friedenreich antibody constructs H2aL2a and H3L3 in human breast and lung cancer xenograft models Research Paper

Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival Research Paper

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma Research Paper

Targeting lipid metabolism in the treatment of ovarian cancer Review

Role of the prorenin receptor in endometrial cancer cell growth Research Paper

Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma Case Report

Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients Research Paper

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity Research Paper

Correction: Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1 Correction

Correction: LncRNA CHRF-induced miR-489 loss promotes metastasis of colorectal cancer via TWIST1/EMT signaling pathway Correction

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper

Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis Research Paper

Control of the Mdm2-p53 signal loop by β-arrestin 2: The ins and outs Editorial

Anti-aging: senolytics or gerostatics (unconventional view) Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Genetic modifiers of p53: opportunities for breast cancer therapies Editorial Perspective

Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells Review

Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss Research Paper

Calcium signaling induced by 15-deoxy-prostamide-J2 promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore Research Paper

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Therapeutic efficacy of the humanized JAA-F11 anti-Thomsen-Friedenreich antibody constructs H2aL2a and H3L3 in human breast and lung cancer xenograft models Research Paper

Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival Research Paper

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy Research Paper

Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma Research Paper

Targeting lipid metabolism in the treatment of ovarian cancer Review

Role of the prorenin receptor in endometrial cancer cell growth Research Paper

Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma Case Report

Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients Research Paper

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity Research Paper

Correction: Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1 Correction

Correction: LncRNA CHRF-induced miR-489 loss promotes metastasis of colorectal cancer via TWIST1/EMT signaling pathway Correction

ATR inhibition reverses the resistance of homologous recombination deficient MGMTlow/MMRproficient cancer cells to temozolomide Priority Research Paper

Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis Research Paper

Control of the Mdm2-p53 signal loop by β-arrestin 2: The ins and outs Editorial

Anti-aging: senolytics or gerostatics (unconventional view) Review

Calcium signaling induced by 15-deoxy-prostamide-J₂ promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore Research Paper

ATR inhibition reverses the resistance of homologous recombination deficient MGMT^low/MMR^proficient cancer cells to temozolomide Priority Research Paper