The Oncosearch | Oncotarget

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Christie P.M. Verkleij, Kristine A. Frerichs, Marloes Broekmans, Saida Absalah, Patricia W.C. Maas-Bosman, Sandy Kruyswijk, Inger S. Nijhof, Tuna Mutis, Sonja Zweegman, Niels W.C.J. van de Donk

Published Oct 24, 2020 · Vol. 11, No. 45 · pp. 4076-4081

Keywords: multiple myeloma, bispecific antibody, immunotherapy, BCMA, CD38

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Niraj Lodhi, Moe Tun, Poonam Nagpal, Arati A. Inamdar, Nehad M. Ayoub, Noor Siyam, Lucia Oton-Gonzalez, Angela Gerona, Dainelle Morris, Rana Sandhu, Kwangsun Stephen Suh

Published Oct 20, 2020 · Vol. 11, No. 44 · pp. 4045-4073

Keywords: DLBCL, diagnosis, R-CHOP, precision medicine, prognosis

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Geraldine O'Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh Do, Jerry M. Collins, Larry Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwara, Richard Piekarz, Howard Streicher, Elad Sharon, Larry Rubinstein, Andrea Regier Voth, Jay Lozier, Angie B. Dull, Deborah Wilsker, Toshinori Hinoue, Peter W. Laird, Katherine V. Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, Alice P. Chen

Published Oct 12, 2020 · Vol. 11, No. 44 · pp. 3959-3971

Keywords: DNA damage repair, base excision repair, MGMT, rational combination therapy, molecular pharmacodynamics

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Sanjeev Pasadi, Kalappa Muniyappa

Published Oct 7, 2020 · Vol. 11, No. 44 · pp. 4028-4044

Keywords: cancer, cisplatin resistance, cisplatin-induced DNA crosslinks, Wnt/β-catenin signalling, Mre11–Rad50–Nbs1 complex

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Mizuho Mitamura, Satoru Kase, Kiriko Hirooka, Susumu Ishida

Published Oct 6, 2020 · Vol. 11, No. 42 · pp. 3800-3804

Keywords: juxtapapillary retinal capillary hemangioblastoma, laser photocoagulation, laser speckle flowgraphy, fluorescein angiography, von Hippel-Lindau disease

Estrogen receptor α polymorphism is associated with dementia in a Brazilian cohort Research Paper

Rafaella Papalino Lopes Magnago, Valerio Garrone Barauna, Bruna Ferro Brun, Ana Cristina Lo Prete, Aline Morgan Alvarenga, Luciene C. Gastalho Campos, Neuza Felix Gomes Rochette, Letícia Batista Azevedo Rangel, Rodrigo Alves Faria, Paulo Caleb Junior Lima Santos, Ian Victor Silva

Published Sep 4, 2020 · Vol. 11, No. 50 · pp. 4655-4660

Keywords: dementia, elderly, estrogen receptor α, polymorphism

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

Renee E. Vickman, Douglas V. Faget, Philip Beachy, David Beebe, Neil A. Bhowmick, Edna Cukierman, Wu-Min Deng, James G. Granneman, Jeffrey Hildesheim, Raghu Kalluri, Ken S. Lau, Ernst Lengyel, Joakim Lundeberg, Jorge Moscat, Peter S. Nelson, Kristian Pietras, Katerina Politi, Ellen Puré, Ruth Scherz-Shouval, Mara H. Sherman, David Tuveson, Ashani T. Weeraratna, Richard M. White, Melissa H. Wong, Elisa C. Woodhouse, Ying Zheng, Simon W. Hayward, Sheila A. Stewart

Published Aug 29, 2020 · Vol. 11, No. 40 · pp. 3621-3632

Keywords: tumor microenvironment, stromal heterogeneity, extracellular matrix, cellular plasticity, therapy resistance

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

Erryk S. Katayama, Jonathan J. Hue, David L. Bajor, Lee M. Ocuin, John B. Ammori, Jeffrey M. Hardacre, Jordan M. Winter

Published Aug 24, 2020 · Vol. 11, No. 38 · pp. 3489-3501

Keywords: pancreatic cancer, pancreatic ductal adenocarcinoma, clinical trial, novel treatment, drug development

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

Dimitra P. Vageli, David Kasle, Sotirios G. Doukas, Panagiotis G. Doukas, Clarence T. Sasaki

Published Aug 3, 2020 · Vol. 11, No. 35 · pp. 3303-3314

Keywords: NF-κB inhibition, BAY 11-7082, bile, laryngopharyngeal reflux, hypopharyngeal cancer

Obinutuzumab (GA101) vs. rituximab significantly enhances cell death, antibody-dependent cytotoxicity and improves overall survival against CD20+ primary mediastinal B-cell lymphoma (PMBL) in a xenograft NOD-scid IL2Rgnull (NSG) mouse model: a potential targeted agent in the treatment of PMBL Research Paper

Yaya Chu, Aradhana Awasthi, Sanghoon Lee, Dina Edani, Changhong Yin, Jessica Hochberg, Tishi Shah, Tae-Hoon Chung, Janet Ayello, Carmella van de Ven, Christian Klein, Dean Lee, Mitchell S. Cairo

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3035-3047

Keywords: Obinutuzumab, rituximab, survival, primary mediastinal large B-cell lymphoma, antibody-dependent cellular cytotoxicity

Correction: SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Correction

Jolein Mijnes, Janina Tiedemann, Julian Eschenbruch, Janina Gasthaus, Sarah Bringezu, Dirk Bauerschlag, Nicolai Maass, Norbert Arnold, Jörg Weimer, Tobias Anzeneder, Peter A. Fasching, Matthias Rübner, Benjamin Bruno, Uwe Heindrichs, Jennifer Freres, Hanna Schulz, Ralf-Dieter Hilgers, Nadina Ortiz-Brüchle, Sonja von Serenyi, Ruth Knüchel, Vera Kloten, Edgar Dahl

Published Jul 16, 2020 · Vol. 11, No. 30 · pp. 2958-2958

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Takeyuki Suzuki, Tetsutaro Suzuki, Yukino Yoshimura, Mitsunori Yahata, Poh Yin Yew, Tetsuya Nakamura, Yusuke Nakamura, Jae-Hyun Park, Ryota Matsuo

Published Jul 15, 2020 · Vol. 11, No. 34 · pp. 3198-3207

Keywords: ctDNA, early detection, liquid biopsy, mutation, recurrence

Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma Research Paper

Lilia Turcios, Francesc Marti, David S. Watt, Lilia M. Kril, Aman Khurana, Fanny Chapelin, Chunming Liu, Joseph B. Zwischenberger, B. Mark Evers, Roberto Gedaly

Published Jul 9, 2020 · Vol. 11, No. 31 · pp. 3013-3024

Keywords: hepatocellular carcinoma, proton uncouplers, Wnt/β-catenin pathway, glutamine metabolism, mitochondria

Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance via immunosuppressive miR-182/miR-217 signaling and p27/CDK6 regulation Research Paper

Kalliopi Domvri, Savvas Petanidis, Doxakis Anestakis, Konstantinos Porpodis, Chong Bai, Paul Zarogoulidis, Lutz Freitag, Wolfgang Hohenforst-Schmidt, Theodora Katopodi

Published Jul 1, 2020 · Vol. 11, No. 29 · pp. 2847-2862

Keywords: PCAT-1, miR-182, immunosuppression, Kras, miR-217

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Abhay Kumar Singh, Vaishali Kapoor, Dinesh Thotala, Dennis E. Hallahan

Published Jun 22, 2020 · Vol. 11, No. 27 · pp. 2647-2659

Keywords: TAF15, radiation inducible, lung cancer, antibody

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

Yue Guan, Christopher B. Chambers, Taylor Tabatabai, Ha Hatley, Kristin R. Delfino, Kathy Robinson, Shaheen R. Alanee, Sophia Ran, Donald S. Torry, Andrew Wilber

Published Jun 12, 2020 · Vol. 11, No. 26 · pp. 2571-2585

Keywords: kidney cancer, innate immunity, natural killer cells, immunosuppression, angiogenesis

Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking Research Paper

Joshua T. Rose, Eliana Moskovitz, Joseph R. Boyd, Jonathan A. Gordon, Nicole A. Bouffard, Andrew J. Fritz, Anuradha Illendula, John H. Bushweller, Jane B. Lian, Janet L. Stein, Sayyed K. Zaidi, Gary S. Stein

Published May 30, 2020 · Vol. 11, No. 26 · pp. 2512-2530

Keywords: mammary epithelial phenotype, epithelial phenotype, RUNX1, CBFβ, mitotic gene bookmarking

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit Research Paper

Hee-Don Chae, Ritika Dutta, Bruce Tiu, Fieke W. Hoff, Benedetta Accordi, Valentina Serafin, Minyoung Youn, Min Huang, Nathan Sumarsono, Kara L. Davis, Norman J. Lacayo, Martina Pigazzi, Terzah M. Horton, Steven M. Kornblau, Kathleen M. Sakamoto

Published May 26, 2020 · Vol. 11, No. 25 · pp. 2387-2403

Keywords: acute myeloid leukemia, BI-D1870, RSK, vincristine, spindle assembly checkpoint

SUSD2 expression correlates with decreased metastasis and increased survival in a high-grade serous ovarian cancer xenograft murine model Research Paper

Jordan N. Sheets, Mitch E. Patrick, Kristi A. Egland

Published May 25, 2020 · Vol. 11, No. 24 · pp. 2290-2301

Keywords: high-grade serous ovarian cancer, SUSD2, xenograft, metastasis

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells Research Paper

Nicholas J. Monteleone, Carol S. Lutz

Published May 22, 2020 · Vol. 11, No. 26 · pp. 2464-2483

Keywords: miR-708-5p, miR-708, lung cancer, COX-2, mPGES-1

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T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Estrogen receptor α polymorphism is associated with dementia in a Brazilian cohort Research Paper

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

Correction: SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Correction

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma Research Paper

Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance via immunosuppressive miR-182/miR-217 signaling and p27/CDK6 regulation Research Paper

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking Research Paper

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit Research Paper

SUSD2 expression correlates with decreased metastasis and increased survival in a high-grade serous ovarian cancer xenograft murine model Research Paper

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma Research Perspective

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links Research Paper

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect Case Report

Estrogen receptor α polymorphism is associated with dementia in a Brazilian cohort Research Paper

Deconstructing tumor heterogeneity: the stromal perspective Meeting Report

A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? Research Paper

The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model Research Paper

Correction: SNiPER: a novel hypermethylation biomarker panel for liquid biopsy based early breast cancer detection Correction

Detection of circulating tumor DNA in patients of operative colorectal and gastric cancers Research Paper

Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma Research Paper

Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance via immunosuppressive miR-182/miR-217 signaling and p27/CDK6 regulation Research Paper

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking Research Paper

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit Research Paper

SUSD2 expression correlates with decreased metastasis and increased survival in a high-grade serous ovarian cancer xenograft murine model Research Paper

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells Research Paper