The Oncosearch | Oncotarget

The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology Research Paper

Artur Kadurin, Alexander Aliper, Andrey Kazennov, Polina Mamoshina, Quentin Vanhaelen, Kuzma Khrabrov, Alex Zhavoronkov

Published Dec 22, 2016 · Vol. 8, No. 7 · pp. 10883-10890

Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer Research Paper

Mingxing Wang, Guoyin Li, Zhiwei Yang, Lei Wang, Lei Zhang, Ting Wang, Yimeng Zhang, Shengli Zhang, Yong Han, Lintao Jia

Published Dec 22, 2016 · Vol. 8, No. 5 · pp. 8083-8094

High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes Research Paper

Marta R. Hidalgo, Cankut Cubuk, Alicia Amadoz, Francisco Salavert, JosÃ© Carbonell-Caballero, Joaquin Dopazo

Published Dec 22, 2016 · Vol. 8, No. 3 · pp. 5160-5178

Drug-induced premature senescence model in human dental follicle stem cells Research Paper

Yuanfen Zhai, Rongbin Wei, Junjun Liu, Huihui Wang, Wenping Cai, Mengmeng Zhao, Yongguang Hu, Shuwei Wang, Tianshu Yang, Xiaodong Liu, Jianhua Yang, Shangfeng Liu

Published Dec 21, 2016 · Vol. 8, No. 5 · pp. 7276-7293

Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes Research Paper

Yu LIU, Ya-Long WANG, Shu-wen HE, Ming-Huang CHEN, Zhen ZHANG, Xian-Pei FU, Bin-Bin FU, Bao-Qiong LIAO, Yan-Hong LIN, Zhong-Quan Qi, Hai-Long Wang

Published Dec 21, 2016 · Vol. 8, No. 4 · pp. 6233-6245

Adenosine 5â€²-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation Research Paper

Xiao Yang, Yibei Zhan, Qi Sun, Xi Xu, Yi Kong, Jianfa Zhang

Published Dec 21, 2016 · Vol. 8, No. 4 · pp. 6273-6282

Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells Research Paper

Jianyun Zhao, Chengzhi Xie, Holly Edwards, Guan Wang, Jeffrey W. Taub, Yubin Ge

Published Dec 21, 2016 · Vol. 8, No. 4 · pp. 6319-6329

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice Research Paper

Halina Was, Kamila Barszcz, Joanna Czarnecka, Agata Kowalczyk, Tytus Bernas, Ewelina Uzarowska, Paulina Koza, Agata Klejman, Katarzyna Piwocka, Bozena Kaminska, Eva Sikora

Published Dec 21, 2016 · Vol. 8, No. 6 · pp. 9303-9322

Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor Research Paper

Elizabeth Wells, Madhuri Kambhampati, Jesse M. Damsker, Heather Gordish-Dressman, Sridevi Yadavilli, Oren J. Becher, Jamila Gittens, Mojca Stampar, Roger J. Packer, Javad Nazarian

Published Dec 21, 2016 · Vol. 8, No. 6 · pp. 9366-9374

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug Research Paper

Takashi Murakami, Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Yong Zhang, Ming Zhao, Yukihiko Hiroshima, Scott D. Nelson, Sarah M. Dry, Yunfeng Li, Jane Yanagawa, Tara Russell, Noah Federman, Arun Singh, Irmina Elliott, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Itaru Endo, Fritz C. Eilber, Robert M. Hoffman

Published Dec 20, 2016 · Vol. 8, No. 5 · pp. 8035-8042

Association between Retinoic acid receptor-Î² hypermethylation and NSCLC risk: a meta-analysis and literature review Research Paper

Yan Li, De-guo Lu, Ying-mei Ma, Hongxiang Liu

Published Dec 19, 2016 · Vol. 8, No. 4 · pp. 5814-5822

Mechanisms of resistance to anti-EGFR therapy in colorectal cancer Research Paper

Ben Zhao, Lu Wang, Hong Qiu, Mingsheng Zhang, Li Sun, Ping Peng, Qianqian Yu, Xianglin Yuan

Published Dec 18, 2016 · Vol. 8, No. 3 · pp. 3980-4000

Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells Research Paper

Qiaoling Song, Xiaoxiao Sun, Hui Guo, Qiang Yu

Published Dec 17, 2016 · Vol. 8, No. 3 · pp. 5003-5015

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing Research Paper

Florian Selt, Juliane Hohloch, Thomas Hielscher, Felix Sahm, David Capper, Andrey Korshunov, Diren Usta, Sebastian Brabetz, Johannes Ridinger, Jonas Ecker, Ina Oehme, Jan Gronych, Viktoria Marquardt, David Pauck, Heidi BÃ¤chli, Charles D. Stiles, Andreas von Deimling, Marc Remke, Martin U. Schuhmann, Stefan M. Pfister, Tilman Brummer, David T.W. Jones, Olaf Witt, Till Milde

Published Dec 17, 2016 · Vol. 8, No. 7 · pp. 11460-11479

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications Research Paper

Benjamin Fourneaux, Vanessa Chaire, Carlo Lucchesi, Marie Karanian, Raphael Pineau, Audrey Laroche-Clary, Antoine Italiano

Published Dec 16, 2016 · Vol. 8, No. 5 · pp. 7878-7890

Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine Priority Research Paper

Erika Maria Parasido, Alessandra Silvestri, Vincenzo Canzonieri, Claudio Belluco, Maria Grazia Diodoro, Massimo Milione, Flavia Melotti, Ruggero De Maria, Lance Liotta, Emanuel F. Petricoin, Mariaelena Pierobon

Published Dec 15, 2016 · Vol. 8, No. 30 · pp. 48534-48544

LHBs can elevate the expression of MDR1 through HIF-1Î± in patients with CHB infection: a comparative proteomic study Research Paper

Shiying Li, Yixuan Yang, Xiangchun Ding, Min Yang, Sha She, Hong Peng, Xiaoming Xu, Xiaoping Ran, Sanglin Li, Peng Hu, Huaidong Hu, Dazhi Zhang, Hong Ren

Published Dec 15, 2016 · Vol. 8, No. 3 · pp. 4549-4562

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The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology Research Paper

Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer Research Paper

High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes Research Paper

Drug-induced premature senescence model in human dental follicle stem cells Research Paper

Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes Research Paper

Adenosine 5â€²-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation Research Paper

Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells Research Paper

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice Research Paper

Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor Research Paper

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug Research Paper

Association between Retinoic acid receptor-Î² hypermethylation and NSCLC risk: a meta-analysis and literature review Research Paper

Mechanisms of resistance to anti-EGFR therapy in colorectal cancer Research Paper

Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells Research Paper

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing Research Paper

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications Research Paper

Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine Priority Research Paper

MicroRNA-30e reduces cell growth and enhances drug sensitivity to gefitinib in lung carcinoma Research Paper

Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound Research Paper

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter Research Paper

LHBs can elevate the expression of MDR1 through HIF-1Î± in patients with CHB infection: a comparative proteomic study Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology Research Paper

Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer Research Paper

High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes Research Paper

Drug-induced premature senescence model in human dental follicle stem cells Research Paper

Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes Research Paper

Adenosine 5â€²-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation Research Paper

Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells Research Paper

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice Research Paper

Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor Research Paper

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug Research Paper

Association between Retinoic acid receptor-Î² hypermethylation and NSCLC risk: a meta-analysis and literature review Research Paper

Mechanisms of resistance to anti-EGFR therapy in colorectal cancer Research Paper

Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells Research Paper

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing Research Paper

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications Research Paper

Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine Priority Research Paper

MicroRNA-30e reduces cell growth and enhances drug sensitivity to gefitinib in lung carcinoma Research Paper

Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound Research Paper

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter Research Paper

LHBs can elevate the expression of MDR1 through HIF-1Î± in patients with CHB infection: a comparative proteomic study Research Paper