The Oncosearch | Oncotarget

Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer Research Paper

Shuying Liu, Xiaolong Meng, Huiqin Chen, Wenbin Liu, Todd Miller, Mandi Murph Yiling Lu, Fan Zhang, Mihai Gagea, Carlos L. Arteaga, Gordon B. Mills, Funda Meric-Bernstam, Ana M. GonzÃ¡lez-Angulo

Published May 27, 2014 · Vol. 5, No. 19 · pp. 9049-9064

Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia Research Paper

Annalisa Pezzolo, Danilo Marimpietri, Lizzia Raffaghello, Claudia Cocco, Angela Pistorio, Claudio Gambini, Michele Cilli, Alberto Horenstein, Fabio Malavasi, Vito Pistoia

Published May 26, 2014 · Vol. 5, No. 21 · pp. 10368-10381

The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target. Research Paper

Maurizio Orlandini, Federico Galvagni, Monia Bardelli, Marina Rocchigiani, Claudia Lentucci, Francesca Anselmi, Alessio Zippo, Luca Bini, Salvatore Oliviero

Published Apr 7, 2014 · Vol. 5, No. 9 · pp. 2750-2760

Discovery and validation of an INflammatory PROtein-driven GAstric cancer Signature (INPROGAS) using antibody microarray-based oncoproteomics Research Paper

Manuel Puig-Costa, Antonio Codina-Cazador, Elisabet CortÃ©s-Pastoret, Cristina Oliveras-Ferraros, SÃlvia CufÃ, SÃlvia Flaquer, Francesca Llopis-Puigmarti, Eulalia Pujol-Amado, Bruna Corominas-Faja, Elisabet CuyÃ s, Rosa Ortiz, Eugeni Lopez-Bonet, Bernardo Queralt, Raquel GuardeÃ±o, BegoÃ±a Martin-Castillo, Josep Roig, Jorge Joven, Javier A. Menendez

Published Mar 31, 2014 · Vol. 5, No. 7 · pp. 1942-1954

KIAA1114, a full-length protein encoded by the trophinin gene, is a novel surface marker for isolating tumor-initiating cells of multiple hepatocellular carcinoma subtypes Priority Research Paper

Sae Won Kim, Hyun Gul Yang, Moon Cheol Kang, Seungwon Lee, Hong Namkoong, Seung-Woo Lee, Young Chul Sung

Published Mar 31, 2014 · Vol. 5, No. 5 · pp. 1226-1240

Keywords: Tumor-initiating cells, hepatocellular carcinoma, KIAA1114, cell surface marker, monoclonal antibody

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor Research Paper

Koichi Azuma, Akihiko Kawahara, Kahori Sonoda, Kazutaka Nakashima, Kousuke Tashiro, Kosuke Watari, Hiroto Izumi, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono, Tomoaki Hoshino

Published Mar 26, 2014 · Vol. 5, No. 15 · pp. 5908-5919

Biomarkers of reactive resistance and early disease progression during chemotherapy plus bevacizumab treatment for colorectal carcinoma Research Paper

Hidetoshi Hayashi, Tokuzo Arao, Kazuko Matsumoto, Hideharu Kimura Kimura, Yosuke Togashi, Yoshinori Hirashima, Yosuke Horita, Satoru Iwasa, Natsuko Tsuda Okita, Yoshitaka Honma, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Yasuhiro Shimada, Kazuhiko Nakagawa, Kazuto Nishio, Yasuhide Yamada

Published Mar 22, 2014 · Vol. 5, No. 9 · pp. 2588-2595

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment Research Paper

Po-Chun Chen, Hsu-Chen Cheng, John Wang, Shin-Wei Wang, Huai-Ching Tai, Chiao-Wen Lin, Chih-Hsin Tang

Published Feb 4, 2014 · Vol. 5, No. 6 · pp. 1595-1608

Keywords: CCN3, VEGF, Prostate cancer, M2 macrophage, angiogenesis

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

Arnau Montraveta, Silvia Xargay-Torrent, MÃ³nica LÃ³pez-Guerra, Laia Rosich, Patricia PÃ©rez-GalÃ¡n, Itziar Salaverria, Silvia BeÃ, Susana G. Kalko, MercÃ¨ de Frias, Clara CampÃ s, GaÃ«l RouÃ©, Dolors Colomer

Published Jan 25, 2014 · Vol. 5, No. 3 · pp. 726-739

Keywords: Acadesine, rituximab, mantle cell lymphoma, xenograft mouse model

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Paul MÃ©sange, Virginie Poindessous, MichÃ¨le Sabbah, Alexandre E. Escargueil, Aimery de Gramont, Annette K. Larsen

Published Jan 20, 2014 · Vol. 5, No. 13 · pp. 4709-4721

Keywords: resistance, angiogenesis inhibition, vascular endothelial growth factor (VEGF)-signaling, hypoxia, bevacizumab, nintedanib

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

Jakob H. Mikkelsen, Zachary T. Resch, Bhanu Kalra, Gopal Savjani, Ajay Kumar, Cheryl A. Conover, Claus Oxvig

Published Jan 17, 2014 · Vol. 5, No. 4 · pp. 1014-1025

Keywords: insulin-like growth factor receptor, pregnancy-associated plasma protein-A, proteolytic inhibition, therapeutic antibody, xenograft mouse model

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Vivek Subbiah, Robert E. Brown, Mary F. McGuire, Jamie Buryanek, Filip Janku, Anas Younes, David Hong

Published Nov 19, 2013 · Vol. 5, No. 1 · pp. 95-102

Keywords: Hodgkin's lymphoma, mTOR, HDAC, Sirolimus, Vorinostat, Targeted therapy

1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-GuÃ©rin immunotherapy of bladder cancer Research Paper

Jong-Wei Hsu, Peng-Nien Yin, Ronald Wood, James Messing, Edward Messing, Yi-Fen Lee

Published Nov 19, 2013 · Vol. 4, No. 12 · pp. 2397-2406

Keywords: vitamin D, Bacillus Calmette-GuÃ©rin, bladder cancer, immunotherapy, interleukin 8

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

Aurelie Poli, Jian Wang, Olivia Domingues, JesÃºs PlanagumÃ, Tao Yan, Kai Ove Skaftnesmo, Cecilie Brekke Rygh, Frits Thorsen, Emmet McCormack, FranÃ§ois Hentges, Paal Henning Pedersen, Jacques Zimmer, Per Ã˜yvind Enger, Martha Chekenya

Published Sep 9, 2013 · Vol. 4, No. 9 · pp. 1527-1546

Keywords: Microglia, NK cells, glioblastoma, immunotherapy, NG2/CSPG4

HER4 expression status correlates with improved outcome in both neoadjuvant and adjuvant Trastuzumab treated invasive breast carcinoma Research Paper

Bryce P Portier, Eugen C. Minca, Zhen Wang, Christopher Lanigan, Aaron M. Gruver, Erinn Downs-Kelly, G. Thomas Budd, Raymond R. Tubbs

Published Aug 26, 2013 · Vol. 4, No. 10 · pp. 1662-1672

Keywords: Breast carcinoma, HER2, HER4, Immunohistochemistry, RT-qPCR, Trastuzumab, H-Score

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Silke KaulfuÃŸ, Henning Seemann, Rovena Kampe, Julia Meyer, Ralf Dressel, Britta KÃ¶nig, Jens-Gerd Scharf, Peter Burfeind

Published Jun 30, 2013 · Vol. 4, No. 7 · pp. 1037-1049

Keywords: colorectal cancer, PDGF receptor, c-KIT, SRC, cell proliferation, apoptosis, RNA interference, targeted therapy

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth Research Paper

Julin Shuxian Wong, Emma Warbrick, Borek Vojtesek, Jeffrey Hill, David Philip Lane

Published Jun 29, 2013 · Vol. 4, No. 7 · pp. 1019-1036

Keywords: c-Met, seeMet 2, monoclonal antibody, temperature sensitive & cryptic epitope

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

Zhigang Xie, Jayantha Gunaratne, Lip Lee Cheong, Shaw Cheng Liu, Tze Loong Koh, Gaofeng Huang, Walter P Blackstock, Wee Joo Chng

Published Jun 26, 2013 · Vol. 4, No. 7 · pp. 1008-1018

Keywords: SILAC, quantitative proteomics, oncotargets, multiple myeloma

CD44variant exon 9 plays an important role in colon cancer initiating cells Research Paper

Youhei Kimura, Takanori Goi, Toshiyuki Nakazawa, Yasuo Hirono, Kanji Katayama, Takeshi Urano, Akio Yamaguchi

Published Jun 6, 2013 · Vol. 4, No. 5 · pp. 785-791

Keywords: CD44 variant exon, stem cells, Cancer initiating cells

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Yunyun Jiang, Filip Janku, Vivek Subbiah, Laura S. Angelo, Aung Naing, Peter M. Anderson, Cynthia E. Herzog, Siqing Fu, Robert S. Benjamin, Razelle Kurzrock

Published Jun 5, 2013 · Vol. 4, No. 6 · pp. 884-889

Keywords: Ewing sarcoma, PTPRD, mutation, germline

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Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer Research Paper

Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia Research Paper

The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target. Research Paper

Discovery and validation of an INflammatory PROtein-driven GAstric cancer Signature (INPROGAS) using antibody microarray-based oncoproteomics Research Paper

KIAA1114, a full-length protein encoded by the trophinin gene, is a novel surface marker for isolating tumor-initiating cells of multiple hepatocellular carcinoma subtypes Priority Research Paper

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor Research Paper

Biomarkers of reactive resistance and early disease progression during chemotherapy plus bevacizumab treatment for colorectal carcinoma Research Paper

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment Research Paper

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-GuÃ©rin immunotherapy of bladder cancer Research Paper

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

HER4 expression status correlates with improved outcome in both neoadjuvant and adjuvant Trastuzumab treated invasive breast carcinoma Research Paper

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth Research Paper

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

CD44variant exon 9 plays an important role in colon cancer initiating cells Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer Research Paper

Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia Research Paper

The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target. Research Paper

Discovery and validation of an INflammatory PROtein-driven GAstric cancer Signature (INPROGAS) using antibody microarray-based oncoproteomics Research Paper

KIAA1114, a full-length protein encoded by the trophinin gene, is a novel surface marker for isolating tumor-initiating cells of multiple hepatocellular carcinoma subtypes Priority Research Paper

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor Research Paper

Biomarkers of reactive resistance and early disease progression during chemotherapy plus bevacizumab treatment for colorectal carcinoma Research Paper

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment Research Paper

Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Research Paper

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

1 alpha, 25-dihydroxylvitamin D3 promotes Bacillus Calmette-GuÃ©rin immunotherapy of bladder cancer Research Paper

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

HER4 expression status correlates with improved outcome in both neoadjuvant and adjuvant Trastuzumab treated invasive breast carcinoma Research Paper

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth Research Paper

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

CD44variant exon 9 plays an important role in colon cancer initiating cells Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper