The Oncosearch | Oncotarget

Epigenetic silencing of HOPX is critically involved in aggressive phenotypes and patient prognosis in papillary thyroid cancer Research Paper

Yosuke Ooizumi, Hiroshi Katoh, Mitsuo Yokota, Masahiko Watanabe, Keishi Yamashita

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5906-5918

Keywords: HOPX, papillary thyroid cancer, epigenetic silencing, promoter methylation

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Shiho Fukui, Kazunori Nagasaka, Yuko Miyagawa, Ryoko Kikuchi-Koike, Yoshiko Kawata, Ranka Kanda, Takayuki Ichinose, Takeru Sugihara, Haruko Hiraike, Osamu Wada-Hiraike, Yuko Sasajima, Takuya Ayabe

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5932-5948

Keywords: ovarian cancer, bAP15, TGF-β/Smad signaling, UCHL5, apoptosis

Correction: Hypericin targets osteoclast and prevents breast cancer-induced bone metastasis via NFATc1 signaling pathway Correction

Zhengxiao Ouyang, Xiaoning Guo, Xia Chen, Bo Liu, Qiang Zhang, Ziqing Yin, Zanjing Zhai, Xinhua Qu, Xuqiang Liu, Dan Peng, Yi Shen, Tang Liu, Qing Zhang

Published Oct 12, 2019 · Vol. 10, No. 58 · pp. 6283-6284

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma Research Paper

Nathan D. Seligson, Colin W. Stets, Bryce W. Demoret, Achal Awasthi, Nicholas Grosenbacher, Reena Shakya, John L. Hays, James L. Chen

Published Oct 1, 2019 · Vol. 10, No. 55 · pp. 5671-5679

Keywords: dedifferentiated liposarcomas, MDM2, HDAC2, romidepsin, MI-192

Clinical significance of evaluating hormone receptor and HER2 protein using cell block against metastatic breast cancer: a multi-institutional study Research Paper

Akira Matsui, Yuya Murata, Norikazu Masuda, Kiyoshi Mori, Masato Takahashi, Katsushige Yamashiro, Kenjirou Aogi, Shigeto Maeda, Masahiro Itou, Shinji Ozaki, Kazuya Kuraoka, Yasuyuki Satou, Shu Ichihara, Eriko Tokunaga, Kenichi Taguchi, Takanori Watanabe, Hiroyoshi Suzuki, Aiko Nagayama, Rieko Nishimura

Published Oct 1, 2019 · Vol. 10, No. 55 · pp. 5680-5689

Keywords: metastatic breast cancer, receptor discordance, cell block, cytological specimen, prognosis

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma Research Paper

Yuzan Kudo, Shiro Kohi, Keiji Hirata, Michael Goggins, Norihiro Sato

Published Sep 24, 2019 · Vol. 10, No. 54 · pp. 5592-5604

Keywords: hyaluronan, synthesis, degradation, pancreatic cancer, prognosis

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

Robert O. Dillman, Gabriel I. Nistor, Bryce T. McLelland, Candace Hsieh, Aleksandra J. Poole, Andrew N. Cornforth, Hans S. Keirstead

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5359-5371

Keywords: programmed cell death protein -1 (PD-1), dendritic cell vaccines, metastatic melanoma

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

Jennifer Bryant, Nikolaos Batis, Anna Clara Franke, Gabriella Clancey, Margaret Hartley, Gordon Ryan, Jill Brooks, Andrew D. Southam, Nicholas Barnes, Joanna Parish, Sally Roberts, Farhat Khanim, Rachel Spruce, Hisham Mehanna

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5229-5244

Keywords: head and neck cancer, drug repurposing, drug repositioning, quinacrine, mepacrine

A prognostic score for overall survival in patients treated with abiraterone in the pre- and post-chemotherapy setting Research Paper

Martin Boegemann, Katrin Schlack, Lena Früchtenicht, Julie Steinestel, Andres Jan Schrader, Yvonne Wennmann, Laura-Maria Krabbe, Okyaz Eminaga

Published Aug 20, 2019 · Vol. 10, No. 49 · pp. 5082-5091

Keywords: risk score, mCRPC, abiraterone, survival, outcome

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss Research Paper

Amro H. Mohammad, Sarah Assadian, Frédéric Couture, Karen J. Lefebvre, Wissal El-Assaad, Veronique Barrès, Veronique Ouellet, Pierre-Luc Boulay, Jieyi Yang, Mathieu Latour, Luc Furic, William Muller, Nahum Sonenberg, Anne-Marie Mes-Masson, Fred Saad, Robert Day, Jose G. Teodoro

Published Aug 13, 2019 · Vol. 10, No. 48 · pp. 4923-4936

Keywords: prostate cancer, PTEN, prorenin receptor, soluble prorenin receptor, V-ATPase complex

Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy Research Paper

Cornelia Schroeder, Elham Navid-Hill, Jan Meiners, Claudia Hube-Magg, Martina Kluth, Georgia Makrypidi-Fraune, Ronald Simon, Franziska Büscheck, Andreas M. Luebke, Cosima Goebel, Dagmar S. Lang, Sören Weidemann, Emily Neubauer, Andrea Hinsch, Frank Jacobsen, Patrick Lebok, Uwe Michl, Dirk Pehrke, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Guido Sauter, Doris Höflmayer

Published Aug 13, 2019 · Vol. 10, No. 48 · pp. 4973-4986

Keywords: ELAC2, HPC2, prostate cancer, prognosis, tissue microarray

CpG promoter hypo-methylation and up-regulation of microRNA-190b in hormone receptor-positive breast cancer Research Paper

Elisabet Frick, Thorkell Gudjonsson, Jorunn Eyfjord, Jon Jonasson, Laufey Tryggvadóttir, Olafur Stefansson, Stefan Sigurdsson

Published Jul 23, 2019 · Vol. 10, No. 45 · pp. 4664-4678

Keywords: breast cancer, microRNA-190b, DNA methylation, prognosis, estrogen receptor

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper

Osamu Ichiyanagi, Hiromi Ito, Sei Naito, Takanobu Kabasawa, Hidenori Kanno, Takafumi Narisawa, Masaki Ushijima, Yuta Kurota, Michinobu Ozawa, Toshihiko Sakurai, Hayato Nishida, Tomoyuki Kato, Mitsunori Yamakawa, Norihiko Tsuchiya

Published Jun 18, 2019 · Vol. 10, No. 40 · pp. 4053-4068

Keywords: renal cell carcinoma, phospho-eIF4E (p-eIF4E), MNK (MAPK-interacting kinase), recurrence-free, epithelial−mesenchymal transition

ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer Research Paper

Mavee Witherspoon, Davinder Sandu, Changyuan Lu, Kehui Wang, Robert Edwards, Anthony Yeung, Ozkan Gelincik, Giovanni Manfredi, Steven Gross, Levy Kopelovich, Steven Lipkin

Published Jun 18, 2019 · Vol. 10, No. 40 · pp. 4004-4017

Keywords: familial adenomatous polyposis, ethylmalonic encephalopathy 1, mitochondrial bioenergetics, aerobic glycolysis, colorectal cancer

Downregulation of Friend Leukemia Integration 1 (FLI1) follows the stepwise progression to gastric adenocarcinoma Research Paper

Armando Del Portillo, Elena V. Komissarova, Aqiba Bokhari, Caitlin Hills, Anne Koehne de Gonzalez, Sarawut Kongkarnka, Helen E. Remotti, Jorge L. Sepulveda, Antonia R. Sepulveda

Published Jun 11, 2019 · Vol. 10, No. 39 · pp. 3852-3864

Keywords: gastric cancer, FLI1, dysplasia, tumor suppressor, methylation

Development, validation, and comparison of gene analysis methods for detecting EGFR mutation from non-small cell lung cancer patients-derived circulating free DNA Research Paper

Masaki Hanibuchi, Akira Kanoh, Takuya Kuramoto, Tatsuro Saito, Makoto Tobiume, Atsuro Saijo, Hiroyuki Kozai, Mayo Kondo, Shun Morizumi, Hiroto Yoneda, Kozo Kagawa, Hirokazu Ogino, Seidai Sato, Hiroshi Kawano, Kenji Otsuka, Yuko Toyoda, Hiroshi Nokihara, Hisatsugu Goto, Yasuhiko Nishioka

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3654-3666

Keywords: non-small cell lung cancer, circulating free DNA, epidermal growth factor receptor mutation, epidermal growth factor receptor-tyrosine kinase inhibitor

1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours Research Paper

Clare T. Butler, Susan A. Kennedy, Amy Buckley, Ronan Doyle, Emer Conroy, William M. Gallagher, Jacintha O’Sullivan, Breandán N. Kennedy

Published Jun 4, 2019 · Vol. 10, No. 38 · pp. 3725-3744

Keywords: colorectal cancer, angiogenesis, cysteinyl leukotriene, drug discovery, xenograft

Adaptive responses in a PARP inhibitor window of opportunity trial illustrate limited functional interlesional heterogeneity and potential combination therapy options Research Paper

Marilyne Labrie, Tae-Beom Kim, Zhenlin Ju, Sanghoon Lee, Wei Zhao, Yong Fang, Yiling Lu, Ken Chen, Pedro Ramirez, Michael Frumovitz, Larissa Meyer, Nicole D. Fleming, Anil K. Sood, Robert L. Coleman, Gordon B. Mills, Shannon N. Westin

Published May 28, 2019 · Vol. 10, No. 37 · pp. 3533-3546

Keywords: poly (ADP-ribose) polymerase inhibitor, combination therapy, adaptive response, ovarian cancer, targeted therapy

Comparative genomic analysis of driver mutations in matched primary and recurrent meningiomas Research Paper

Joshua Loewenstern, John Rutland, Corey Gill, Hanane Arib, Margaret Pain, Melissa Umphlett, Yayoi Kinoshita, Russell McBride, Michael Donovan, Robert Sebra, Joshua Bederson, Mary Fowkes, Raj Shrivastava

Published May 28, 2019 · Vol. 10, No. 37 · pp. 3506-3517

Keywords: meningioma, tumor recurrence, genomics, driver mutation, progression-free survival

Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes Research Paper

Nicole E. James, Lindsey Beffa, Matthew T. Oliver, Ashley D. Borgstadt, Jenna B. Emerson, Clinton O. Chichester, Naohiro Yano, Richard N. Freiman, Paul A. DiSilvestro, Jennifer R. Ribeiro

Published May 21, 2019 · Vol. 10, No. 36 · pp. 3315-3327

Keywords: DUSP6, HE4, ovarian cancer, chemoresistance, ERK signaling

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Epigenetic silencing of HOPX is critically involved in aggressive phenotypes and patient prognosis in papillary thyroid cancer Research Paper

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Correction: Hypericin targets osteoclast and prevents breast cancer-induced bone metastasis via NFATc1 signaling pathway Correction

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma Research Paper

Clinical significance of evaluating hormone receptor and HER2 protein using cell block against metastatic breast cancer: a multi-institutional study Research Paper

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma Research Paper

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

A prognostic score for overall survival in patients treated with abiraterone in the pre- and post-chemotherapy setting Research Paper

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss Research Paper

Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy Research Paper

CpG promoter hypo-methylation and up-regulation of microRNA-190b in hormone receptor-positive breast cancer Research Paper

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper

ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer Research Paper

Downregulation of Friend Leukemia Integration 1 (FLI1) follows the stepwise progression to gastric adenocarcinoma Research Paper

Development, validation, and comparison of gene analysis methods for detecting EGFR mutation from non-small cell lung cancer patients-derived circulating free DNA Research Paper

1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours Research Paper

Adaptive responses in a PARP inhibitor window of opportunity trial illustrate limited functional interlesional heterogeneity and potential combination therapy options Research Paper

Comparative genomic analysis of driver mutations in matched primary and recurrent meningiomas Research Paper

Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Epigenetic silencing of HOPX is critically involved in aggressive phenotypes and patient prognosis in papillary thyroid cancer Research Paper

The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer Research Paper

Correction: Hypericin targets osteoclast and prevents breast cancer-induced bone metastasis via NFATc1 signaling pathway Correction

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma Research Paper

Clinical significance of evaluating hormone receptor and HER2 protein using cell block against metastatic breast cancer: a multi-institutional study Research Paper

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma Research Paper

Preliminary observations on soluble programmed cell death protein-1 as a prognostic and predictive biomarker in patients with metastatic melanoma treated with patient-specific autologous vaccines Research Paper

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

A prognostic score for overall survival in patients treated with abiraterone in the pre- and post-chemotherapy setting Research Paper

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss Research Paper

Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy Research Paper

CpG promoter hypo-methylation and up-regulation of microRNA-190b in hormone receptor-positive breast cancer Research Paper

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma Research Paper

ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer Research Paper

Downregulation of Friend Leukemia Integration 1 (FLI1) follows the stepwise progression to gastric adenocarcinoma Research Paper

Development, validation, and comparison of gene analysis methods for detecting EGFR mutation from non-small cell lung cancer patients-derived circulating free DNA Research Paper

1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours Research Paper

Adaptive responses in a PARP inhibitor window of opportunity trial illustrate limited functional interlesional heterogeneity and potential combination therapy options Research Paper

Comparative genomic analysis of driver mutations in matched primary and recurrent meningiomas Research Paper

Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes Research Paper