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Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression Review

Ilaria Sciamanna, Alberto Gualtieri, Pier Vincenzo Piazza, Corrado Spadafora

Published Oct 29, 2014 · Vol. 5, No. 18 · pp. 8039-8051

Keywords: Retrotransposon, reverse transcriptase, inhibitor, non coding RNA, cancer therapy

A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization Research Paper

Min He, Xin Hu, Li Chen, A-Yong Cao, Ke-Da Yu, Ting-Yan Shi, Xia-Ying Kuang, Wen-Biao Shi, Hong Ling, Shan Li, Feng Qiao, Ling Yao, Qingyi Wei, Gen-Hong Di, Zhi-Ming Shao

Published Oct 22, 2014 · Vol. 5, No. 23 · pp. 12218-12232

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation Priority Research Paper

Ying Yan, Ashley L. Hein, Asserewou Etekpo, Katrina M. Burchett, Chi Lin, Charles A. Enke, Surinder K. Batra, Kenneth H. Cowan, Michel M. Ouellette

Published Oct 21, 2014 · Vol. 5, No. 21 · pp. 10251-10270

Keywords: ATM/ATR, clonogenic survival, G2 checkpoint, irradiation, radiosensitivity Running title: Rac1 inhibition radiosensitizes pancreatic cancer cells

AMACR amplification and overexpression in primary imatinib-naÃ¯ve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis Research Paper

Chien-Feng Li, Li-Tzong Chen, Jui Lan, Fong-Fu Chou, Ching-Yih Lin, Yen-Yang Chen, Tzu-Ju Chen, Shau-Hsuan Li, Shih-Chen Yu, Fu-Ming Fang, Hui-Chun Tai, Hsuan-Ying Huang

Published Oct 18, 2014 · Vol. 5, No. 22 · pp. 11588-11603

Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide Research Paper

Kit Man Chai, Chih-Yen Wang, Hung-Jiun Liaw, Kuan-Min Fang, Chung-Shi Yang, Shun-Fen Tzeng

Published Oct 7, 2014 · Vol. 5, No. 21 · pp. 10901-10915

Keywords: BRCC3, BRCC36, ï§H2AX, DNA repair, Glioblastoma

Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions Clinical Research Papers

Kazuko Sakai, Shinsuke Kazama, Yuzo Nagai, Koji Murono, Toshiaki Tanaka, Soichiro Ishihara, Eiji Sunami, Shuta Tomida, Kazuto Nishio, Toshiaki Watanabe

Published Oct 7, 2014 · Vol. 5, No. 20 · pp. 9641-9649

Pilot study of p62 DNA vaccine in dogs with mammary tumors Research Paper

Vladimir Gabai, Franco M. Venanzi, Elena Bagashova, Oksana Rud, Francesca Mariotti, Cecilia Vullo, Giuseppe Catone, Michael Y. Sherman, Antonio Concetti, Andrey Chursov, Anastasia Latanova, Vita Shcherbinina, Victor Shifrin, Alexander Shneider

Published Sep 25, 2014 · Vol. 5, No. 24 · pp. 12803-12810

Pharmacological targeting the ATRâ€“CHK1â€“WEE1 axis involves balancing cell growth stimulation and apoptosis Research Paper

Joyce P.Y. Mak, Wing Yu Man, Hoi Tang Ma, Randy Y.C. Poon

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10546-10557

SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/Î²-catenin pathway Research Paper

Xin Tong, Lili Li, Xiaoyan Li, Lei Heng, Lan Zhong, Xianwei Su, Rong Rong, Shi Hu, Wenjia Liu, Baoqing Jia, Xing Liu, Geng Kou, Jun Han, Shangjing Guo, Yi Hu, Cheng Li, Qian Tao, Yajun Guo

Published Sep 25, 2014 · Vol. 5, No. 21 · pp. 10571-10583

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer Research Paper

Shujie Yang, Yichen Jia, Xiaoyue Liu, Christopher Winters, Xinjun Wang, Yuping Zhang, Eric J. Devor, Adriann M. Hovey, Henry D. Reyes, Xue Xiao, Yang Xu, Donghai Dai, Xiangbing Meng, Kristina W. Thiel, Frederick E. Domann, Kimberly K. Leslie

Published Sep 22, 2014 · Vol. 5, No. 20 · pp. 9783-9797

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity Priority Research Paper

Dongshi Chen, Lihua Ming, Fangdong Zou, Ye Peng, Bennett Van Houten, Jian Yu, Lin Zhang

Published Sep 22, 2014 · Vol. 5, No. 18 · pp. 8107-8122

TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells Research Paper

Selina K. Sutton, Jessica Koach, Owen Tan, Bing Liu, Daniel R. Carter, James S. Wilmott, Benafsha Yosufi, Lauren E. Haydu, Graham J. Mann, John F. Thompson, Georgina V. Long, Tao Liu, Grant McArthur, Xu Dong Zhang, Richard A. Scolyer, Belamy B. Cheung, Glenn M. Marshall

Published Sep 20, 2014 · Vol. 5, No. 20 · pp. 10127-10139

Keywords: Melanoma, TRIM16, BRAF inhibitor, cell migration, IFNÎ²1

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy Research Paper

Estefania Martino-Echarri, Beric R. Henderson, Mariana G. Brocardo

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 9889-9900

HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy Research Paper

Ganji Purnachandra Nagaraju, Olatunji B. Alese, Jerome Landry, Roberto Diaz, Bassel F. El-Rayes

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 9980-9991

The IGF signalling pathway in Wilms tumours - A report from the ENCCA Renal Tumours Biology-driven drug development workshop Review

Mariana Maschietto, Jocelyn Charlton, Daniela Perotti, Paolo Radice, James I. Geller, Kathy Pritchard-Jones, Mark Weeks

Published Sep 16, 2014 · Vol. 5, No. 18 · pp. 8014-8026

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer Research Paper

Daniel J. Sharpe, Katy S. Orr, Michael Moran, Sharon J. White, Stephen McQuaid, Terence R. Lappin, Alexander Thompson, Jacqueline A. James

Published Sep 16, 2014 · Vol. 5, No. 18 · pp. 8803-8815

Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells Priority Research Paper

Lan Yi, Yvonne Sun, Arnold Levine

Published Sep 10, 2014 · Vol. 5, No. 19 · pp. 8924-8936

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis Research Paper

Ryan A. Hlady, Rochelle L. Tiedemann, William Puszyk, Ivan Zendejas, Lewis R. Roberts, Jeong-Hyeon Choi, Chen Liu, Keith D. Robertson

Published Sep 8, 2014 · Vol. 5, No. 19 · pp. 9425-9443

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition Priority Research Paper

Catherine Wilson, Katrina Nicholes, Daisy Bustos, Eva Lin, Qinghua Song, Jean-Philippe Stephan, Donald S. Kirkpatrick, Jeff Settleman

Published Aug 27, 2014 · Vol. 5, No. 17 · pp. 7328-7341

Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth Research Paper

Juan Huertas-MartÃnez, Santiago Rello-Varona, David Herrero-MartÃn, Ignasi Barrau, Silvia GarcÃa-MonclÃºs, Miguel SÃ¡inz-Jaspeado, Laura Lagares-Tena, Yaiza NÃºÃ±ez-Ãlvarez, Silvia Mateo-Lozano, Jaume Mora, Josep Roma, Nuria Toran, Sebastian Moran, Roser LÃ³pez-Alemany, Soledad Gallego, Manel Esteller, Miguel A. Peinado, Xavier GarcÃa del Muro, Oscar M. Tirado

Published Aug 27, 2014 · Vol. 5, No. 20 · pp. 9744-9755

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Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression Review

A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization Research Paper

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation Priority Research Paper

AMACR amplification and overexpression in primary imatinib-naÃ¯ve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis Research Paper

Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide Research Paper

Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions Clinical Research Papers

Pilot study of p62 DNA vaccine in dogs with mammary tumors Research Paper

Pharmacological targeting the ATRâ€“CHK1â€“WEE1 axis involves balancing cell growth stimulation and apoptosis Research Paper

SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/Î²-catenin pathway Research Paper

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer Research Paper

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity Priority Research Paper

TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells Research Paper

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy Research Paper

HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy Research Paper

The IGF signalling pathway in Wilms tumours - A report from the ENCCA Renal Tumours Biology-driven drug development workshop Review

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer Research Paper

Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells Priority Research Paper

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis Research Paper

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition Priority Research Paper

Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression Review

A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization Research Paper

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation Priority Research Paper

AMACR amplification and overexpression in primary imatinib-naÃ¯ve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis Research Paper

Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide Research Paper

Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions Clinical Research Papers

Pilot study of p62 DNA vaccine in dogs with mammary tumors Research Paper

Pharmacological targeting the ATRâ€“CHK1â€“WEE1 axis involves balancing cell growth stimulation and apoptosis Research Paper

SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/Î²-catenin pathway Research Paper

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer Research Paper

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity Priority Research Paper

TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells Research Paper

Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy Research Paper

HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy Research Paper

The IGF signalling pathway in Wilms tumours - A report from the ENCCA Renal Tumours Biology-driven drug development workshop Review

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer Research Paper

Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells Priority Research Paper

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis Research Paper

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition Priority Research Paper

Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth Research Paper