Research Papers:

CYR61 (CCN1) is a metastatic biomarker of gastric cardia adenocarcinoma

Jing Wei _, Guanzhen Yu, Genbao Shao, Aiqin Sun, Miao Chen, Wannian Yang and Qiong Lin

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Oncotarget. 2016; 7:31067-31078. https://doi.org/10.18632/oncotarget.8845

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Jing Wei1, Guanzhen Yu2, Genbao Shao1, Aiqin Sun1, Miao Chen1,3, Wannian Yang1, Qiong Lin1

1School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China

2Changzheng Hospital, Shanghai, China

3The Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu, China

Correspondence to:

Qiong Lin, e-mail: [email protected]

Wannian Yang, e-mail: [email protected]

Keywords: gastric cardia adenocarcinoma, CYR61, prognostic biomarker, metastasis, cell migration

Received: January 04, 2016    Accepted: March 31, 2016    Published: April 20, 2016


Gastric cardia adenocarcinoma (GCA) is the most aggressive subtype of gastric cancer with a high metastatic rate. In this report, we collected tumor tissue samples from 214 GCA cases and examined expression of CYR61, a target gene product of the Hippo-YAP/TAZ pathway, in the GCA tumors by immunohistochemical (IHC) staining using the tissue microarray assay (TMA). The results have shown that CYR61 is overexpressed in 44% of the GCA tumor samples. Expression of CYR61 is inversely correlated with cumulative survival of GCA patients (p<0.001) and significantly associated only with metastatic pathological categories (with N category, p=0.052; with TNM stage, p=0.001). Furthermore, knockdown of CYR61 in gastric cancer AGS cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis. Thus, our studies have established CYR61 as a metastatic biomarker for prediction of poor prognosis of GCA and provided a potential molecular target for anti-metastatic therapy of GCA.

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