Prognostic effect of pregnancy on young female patients with nasopharyngeal carcinoma: results from a matched cohort analysis
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Lu Zhang1,2,*, Huai Liu4,5,6,*, Lin-Quan Tang1,2, Qiu-Yan Chen1,2, Shan-Shan Guo1,2, Li-Ting Liu1,2, Ling Guo1,2, Hao-Yuan Mo1,2, Chong Zhao1,2, Xiang Guo1,2, Ka-Jia Cao1,2, Chao-Nan Qian1,2, Mu-Sheng Zeng1, Jian-Yong Shao1,7, Ying Sun1,8, Jun Ma1,8, Ming-Huang Hong1,3, Hai-Qiang Mai1,2
1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
2Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China
3GCP center, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China
4Department of Radiotherapy, Hunan Cancer Hospital, Changsha, P. R. China
5Department of Radiotherapy, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P. R. China
6Key Laboratory of Translational Radiation Oncology, Changsha, P. R. China
7Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China
8Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, P. R. China
*These authors contributed equally to this work
Ming-Huang Hong, e-mail: [email protected]
Hai-Qiang Mai, e-mail: [email protected]
Keywords: nasopharyngeal carcinoma, pregnancy, prognosis, survival
Received: December 10, 2015 Accepted: February 21, 2016 Published: March 09, 2016
Objectives: We aimed to evaluate the prognosis of pregnancy-associated patients with nasopharyngeal carcinoma (NPC) in a young population.
Methods: From June 1999 to December 2010, 51 patients aged ≤ 35 years who were diagnosed with NPC during pregnancy or within one year after delivery were admitted into the pregnancy-associated group in our institution. An additional 51 patients who were not pregnant at diagnosis were selected from 451 patients based on the matching criteria to match the pregnancy-associated female patients. The primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS) and distant-metastasis failure-free survival (DMFS) and locoregional failure-free survival (LRFS).
Results: The advanced stage was not different between the pregnant and the non-pregnant group before matching (69.8% vs. 70.3%, P = 0.690). No difference in OS at the median follow-up time of 92 months was observed between the pregnancy-associated and the non-pregnant group (85.4% vs. 92.2%, P = 0.478); likewise, no differences were observed regarding PFS and DMFS. However, the pregnancy-associated group had worse LRFS than the non-pregnant group (84.8% vs. 95.9%, P = 0.033). When the pregnancy-associated patients were dichotomized into an early pregnancy group and a late pregnancy group, our data showed that pregnancy interval did not seem to impact the risk of death or relapse.
Conclusion: Our results show that patients in the pregnant group did not seem to have more advanced stage or inferior survival than that in the non-pregnant group.
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