Oncotarget

Research Papers:

DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis

Hyeong Sim Choi, Kangwook Lee, Min Kyoung Kim, Kang Min Lee, Yong Cheol Shin, Sung-Gook Cho and Seong-Gyu Ko _

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Oncotarget. 2016; 7:21775-21785. https://doi.org/10.18632/oncotarget.7982

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Abstract

Hyeong Sim Choi1, Kangwook Lee1, Min Kyoung Kim1, Kang Min Lee1, Yong Cheol Shin2, Sung-Gook Cho3, Seong-Gyu Ko2

1Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 1 Hoegi, Seoul 130-701, Korea

2Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi, Seoul 130-701, Korea

3Department of Biotechnology, Korea National University of Transportation, Jeungpyeong, Chungbuk 368-701, Korea

Correspondence to:

Sung-Gook Cho, e-mail: [email protected]

Seong-Gyu Ko, e-mail: [email protected]

Keywords: DSGOST, angiogenesis, tumor, VEGF, herbal medicine

Received: August 06, 2015     Accepted: February 16, 2016     Published: March 08, 2016

ABSTRACT

Tumor growth requires a process called angiogenesis, a new blood vessel formation from pre-existing vessels, as newly formed vessels provide tumor cells with oxygen and nutrition. Danggui-Sayuk-Ga-Osuyu-Saenggang-Tang (DSGOST), one of traditional Chinese medicines, has been widely used in treatment of vessel diseases including Raynaud’s syndrome in Northeast Asian countries including China, Japan and Korea. Therefore, we hypothesized that DSGOST might inhibit tumor growth by targeting newly formed vessels on the basis of its historical prescription. Here, we demonstrate that DSGOST inhibits tumor growth by inhibiting VEGF-induced angiogenesis. DSGOST inhibited VEGF-induced angiogenic abilities of endothelial cells in vitro and in vivo, which resulted from its inhibition of VEGF/VEGFR2 interaction. Furthermore, DSGOST attenuated pancreatic tumor growth in vivo by reducing angiogenic vessel numbers, while not affecting pancreatic tumor cell viability. Thus, our data conclude that DSGOST inhibits VEGF-induced tumor angiogenesis, suggesting a new indication for DSGOST in treatment of cancer.


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