Serum Helicobacter pylori FliD antibody and the risk of gastric cancer
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Hailin Li1, Bing Zhang1, Xiaomeng Hu1, Yingzi Dong1, Qing Fan2, Fang Guo1, Xiyun Ren1, Haibo Zhou1, Wenjing Tian1, Yashuang Zhao1
1Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China
2Xiangfang Center for Disease Control and Prevention, Harbin, Heilongjiang Province, P. R. China
Wenjing Tian, email: [email protected]
Yashuang, Zhao, email: [email protected]
Keywords: H. pylori FliD protein, H. pylori CagA protein, serum antibody, gastric cancer, case-control study
Received: November 07, 2015 Accepted: February 23, 2016 Published: March 8, 2016
FliD and CagA are important virulence factors of H. pylori. We aimed to evaluate the screening values of FliD and CagA for gastric cancer (GC). Serum samples were obtained from 232 cases and 266 controls in a case-control study. Unconditional multivariate logistic regression with odds ratios (ORs) and 95% confidence intervals (CIs) was used to analyze the relationships between FliD, CagA and GC. The sensitivities, specificities and receiver operating characteristic (ROC) curves were calculated. Finally, the combined screening values of FliD, FlaA, NapA and CagA were assessed based on discriminant analysis. In all subjects, the associations of FliD and CagA with GC were evident with ORs (95% CIs) of 7.6 (4.7-12.3) and 2.5 (1.6-3.8), respectively (*p<0.001). The areas under ROC curves (AUCs) for FliD and CagA were 0.800 and 0.653, respectively. The AUC for the combination of FliD, FlaA and NapA was 0.915, which represented an increase of 0.115 over that of FliD alone (*p<0.001). These findings indicate that the FliD antibody is associated with GC and could exhibit high validity as a biomarker in screening for GC patients. The combination of FliD, FlaA and NapA improved the screening validity.
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