Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1

Miriam Mints; Muhammad Mushtaq; Natalia Iurchenko; Larysa Kovalevska; Maria C. Stip; Daria Budnikova; Sonia Andersson; Ludmila Polischuk; Lubov Buchynska; Elena Kashuba

doi:10.18632/oncotarget.7905

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1

Miriam Mints _, Muhammad Mushtaq, Natalia Iurchenko, Larysa Kovalevska, Maria C. Stip, Daria Budnikova, Sonia Andersson, Ludmila Polischuk, Lubov Buchynska and Elena Kashuba

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2016; 7:22150-22158. https://doi.org/10.18632/oncotarget.7905

Metrics: PDF 1097 views | HTML 2008 views | ?

Abstract

Miriam Mints1,*, Muhammad Mushtaq2,*, Natalia Iurchenko3, Larysa Kovalevska3, Maria C Stip2, Daria Budnikova3, Sonia Andersson1, Ludmila Polischuk3, Lubov Buchynska3, Elena Kashuba2,3

1Department of Women's and Children's Health (KBH), Karolinska Institutet, Stockholm, 17176, Sweden

2Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, 17177, Sweden

3R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Kyiv, 03022, Ukraine

*The authors have equally contributed to this work

Correspondence to:

Elena Kashuba, e-mail: [email protected]

Keywords: endometrial cancer, mitochondrial ribosomal protein MRPS18-2, cell transformation, E2F1, prognostic markers

Received: January 13, 2016 Accepted: February 21, 2016 Published: March 3, 2016

ABSTRACT

Endometrial cancer (EC) is one of the most frequent causes of cancer death among women in developed countries. Histopathological diagnosis and imaging techniques for EC are limited, thus new prognostic markers are needed to offer patients the best treatment and follow-up.

In the present paper we showed that the level of mitochondrial ribosomal protein MRPS18-2 (S18-2) increased in EC compared with the normal endometrium and hyperplasia, based on a study of 42 patient biopsies. Importantly, high expression of free E2F1 in EC correlates well with high S18-2 expression. The EC cell line HEC-1-A, which overexpresses S18-2 constitutively, showed an increased proliferation capacity in vitro and in vivo (in SCID mice). Moreover, pan-keratin, beta-catenin and E-cadherin signals are diminished in these cells, compared to the parental HEC-1-A line, in contrast to vimentin signal that is increased. This may be associated with epithelial-mesenchymal cell transition (EMT).

We conclude that high expression of S18-2 and free E2F1, and low pan-keratin, beta-catenin, and E-cadherin signals might be a good set of prognostic markers for EC.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 7905

Publication Alerts

Research Papers:

Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1

Abstract