Oncotarget

Research Papers:

The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer

Mitsuru Okuno _, Ichiro Yasuda, Seiji Adachi, Masanori Nakashima, Junji Kawaguchi, Shinpei Doi, Takuji Iwashita, Yoshinobu Hirose, Osamu Kozawa, Naoki Yoshimi, Masahito Shimizu and Hisataka Moriwaki

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:14291-14299. https://doi.org/10.18632/oncotarget.7424

Metrics: PDF 1384 views  |   HTML 1898 views  |   ?  


Abstract

Mitsuru Okuno1, Ichiro Yasuda1, Seiji Adachi1, Masanori Nakashima1, Junji Kawaguchi1, Shinpei Doi1, Takuji Iwashita1, Yoshinobu Hirose2, Osamu Kozawa3, Naoki Yoshimi4, Masahito Shimizu1, Hisataka Moriwaki1

1Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan

2Department of Pathology, Osaka Medical College, Takatsuki, Osaka, 569-8686, Japan

3Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan

4Department of Pathology and Oncology, Graduate School of Medical Science, University of the Ryukyus, Nishihara-cho, Okinawa, 903-0215, Japan

Correspondence to:

Mitsuru Okuno, e-mail: [email protected]

Ichiro Yasuda, e-mail: [email protected]

Keywords: HSP27, phosphorylation, pancreatic cancer, prognosis

Received: August 02, 2015     Accepted: January 31, 2016     Published: February 16, 2016

ABSTRACT

Background and Aim: The precise role of phosphorylated heat shock protein (HSP) 27 (p-HSP27) in pancreatic cancer remains to be elucidated. The aim of this study was to investigate whether the expression of p-HSP27 predicts the prognosis of patients with pancreatic cancer.

Methods: We retrospectively assessed 49 biopsied pancreatic cancer tissue samples that were obtained prior to the treatment with gemcitabine. The correlations between p-HSP27 and the clinicopathological characteristics were analyzed.

Results: p-HSP27 was not correlated with the response to chemotherapy or histological type. However, the median survival time was significantly longer in the patients with high p-HSP27 (275 days, n = 18) than those with low p-HSP27 (205 days, n = 31) (P = 0.0158). A multivariate Cox proportional hazards regression analysis revealed that low p-HSP27 predicted a worse prognosis.

Conclusions: Higher p-HSP27 expression before chemotherapy was correlated with better survival, indicating that p-HSP27 expression could be used to predict the prognosis of pancreatic cancer.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 7424