Oncotarget

Research Papers:

Parabolic relationship between sex-specific serum high sensitive C reactive protein and non-alcoholic fatty liver disease in chinese adults: a large population-based study

Li-Ren Wang, Wen-Yue Liu, Sheng-Jie Wu, Gui-Qi Zhu, Yi-Qian Lin, Martin Braddock, Dong-Chu Zhang and Ming-Hua Zheng _

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Oncotarget. 2016; 7:14241-14250. https://doi.org/10.18632/oncotarget.7401

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Abstract

Li-Ren Wang1,2, Wen-Yue Liu3, Sheng-Jie Wu4, Gui-Qi Zhu1,2, Yi-Qian Lin1,5, Martin Braddock6, Dong-Chu Zhang7, Ming-Hua Zheng1,8

1Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

2School of The First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China

3Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

4Department of Cardiovascular Medicine, The Heart Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

5Renji School of Wenzhou Medical University, Wenzhou, China

6Global Medicines Development, AstraZeneca R&D, Alderley Park, United Kingdom

7Wenzhou Medical Center, Wenzhou People’s Hospital, Wenzhou, China

8Institute of Hepatology, Wenzhou Medical University, Wenzhou, China

Correspondence to:

Ming-Hua Zheng, e-mail: [email protected]

Keywords: serum high sensitive C reactive protein, non-alcoholic fatty liver disease, sex-specific, risk factor

Received: December 05, 2015     Accepted: February 04, 2016     Published: February 15, 2016

ABSTRACT

Objectives: To evaluate the association between sex-specific serum high sensitive C reactive protein (hsCRP) levels and NAFLD in a large population-based study.

Results: From Q1 to Q4, the incidence ratios were 21.1 (95% CI 17.5 24.7), 18.6 (95% CI 16.5 20.8), 24.8 (95% CI 22.4 27.2) and 31.1 (95% CI 28.5 33.6) in males and 6.2 (95% CI 4.4 8.0), 6.0 (95% CI 5.1 7.1), 11.4 (95% CI 9.2 13.7) and 19.5 (95% CI 16.1 22.9) in females. Compared with a 1.7-fold increase (Q4 vs Q2) in males, actuarial incidence increased 3.3-fold (Q4 vs Q2) in females. After adjusting for known confounding variables in this study, in the longitudinal population, compared with the reference group, those in Q1, Q3, and Q4 had HRs of 1.63 (95% CI 1.29-2.05), 1.11 (95% CI 0.93-1.31), 1.14 (95% CI 0.97-1.35) in male and 1.77 (95% CI 1.25-2.49), 1.22 (95% CI 0.93-1.59), 1.36 (95% CI 1.03-1.80) in female for NAFLD, respectively.

Methods: 8618 subjects from Wenzhou Medical Center of Wenzhou People’s Hospital were included. Sex specific hsCRP quartiles (Q1 to Q4) were defined: 0-0.1, 0.2-0.4, 0.5-0.8 and 0.9-25.9 for male; 0-0.1, 0.2-0.6, 0.7-1.2 and1.3-28.4 for female. Applying Q2 as reference, Hazard ratios (HRs) and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of hsCRP.

Conclusions: We report that a sex-specific hsCRP level is independently associated with NAFLD. The association between hsCRP and NAFLD was significantly stronger in females than in males.


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