Clinical Research Papers:

Cervical cancer systemic inflammation score: a novel predictor of prognosis

Ru-ru Zheng, Min Huang, Chu Jin, Han-chu Wang, Jiang-tao Yu, Lin-chai Zeng, Fei-yun Zheng and Feng Lin _

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Oncotarget. 2016; 7:15230-15242. https://doi.org/10.18632/oncotarget.7378

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Ru-ru Zheng1*, Min Huang1*, Chu Jin2*, Han-chu Wang1, Jiang-tao Yu1, Lin-chai Zeng1, Fei-yun Zheng1 and Feng Lin1

1 The Department of Gynecology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, Wenzhou, PR China

2 The Department of Information and Engineering, Wenzhou Medical University, Zhejiang, Wenzhou, PR China

* These authors have contributed equally to this work

Correspondence to:

Fei-yun Zheng, email:

Feng Lin, email:

Keywords: cervical cancer, platelet to lymphocyte ratio, albumin, overall survival, disease free survival

Received: November 24, 2015 Accepted: February 01, 2016 Published: February 14, 2016


Inflammation contributes to development and progression in a variety of cancers, including cervical cancer. We developed a novel cervical cancer systemic inflammation score (CCSIS) based on the preoperative platelet-to-lymphocyte ratio (PLR) and serum albumin levels. A retrospective analysis of clinical data from 795 patients with operable cervical cancer was then conducted to investigate the prognostic value of CCSIS and its association with the patients’ clinicopathological features, overall survival (OS), and disease-free survival (DFS). CCSIS was predictive of OS and DFS. High CCSIS was correlated with more advanced FIGO stages, poor tumor differentiation, and the presence of PLN and LVSI. Both albumin levels and the PLR were independent prognostic indicators for operable cervical cancer. The use of the CCSIS could improve risk stratification and traditional clinicopathological analysis in cervical cancer.

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