Oncotarget

Research Papers:

Trop2 is overexpressed in gastric cancer and predicts poor prognosis

Wei Zhao, Huijun Zhu, Shu Zhang, Hongmei Yong, Wei Wang, Yan Zhou, Bing Wang, Jinbo Wen, Zhenning Qiu, Guipeng Ding, Zhenqing Feng _ and Jin Zhu

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Oncotarget. 2016; 7:6136-6145. https://doi.org/10.18632/oncotarget.6733

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Abstract

Wei Zhao1,2,*, Huijun Zhu3,*, Shu Zhang3, Hongmei Yong4, Wei Wang3, Yan Zhou5, Bing Wang5, Jinbo Wen6, Zhenning Qiu7, Guipeng Ding1, Zhenqing Feng1,7,8,9, Jin Zhu7,10

1Department of Pathology, Nanjing Medical University, Nanjing 210029, China

2School of Public Health, Nantong University, Nantong 226019, China

3Department of Pathology, Affiliated Hospital of Nantong University, Nantong 226019, China

4Department of Oncology, Huai’an Hospital Affiliated of Xuzhou Medical College and Huai’an Second People’s Hospital, Huai’an 223001, China

5Department of Oncology, AoYoung Hospital, Zhangjiagang, Jiangsu 215617, China

6Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 210029, China

7Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 210029, China

8Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 210029, China

9Key Laboratory of Cancer Biomarkers, Prevent and Treatment, Cancer Center, Nanjing Medical University, Nanjing 210029, China

10Huadong Medical Institute of Biotechniques, Nanjing 210029, China

*These authors contributed equally to this work

Correspondence to:

Zhenqing Feng, e-mail: fengzhenqing@njmu.edu.cn

Jin Zhu, e-mail: zhujin1968@njmu.edu.cn

Keywords: Trop2, prognosis, gastric cancer

Received: August 03, 2015     Accepted: December 08, 2015     Published: December 22, 2015

ABSTRACT

The cell surface protein Trop2 is overexpressed in a variety of human cancers. Trop2 expression increases tumor development and metastasis and reduces patient survival. However, little is known about the role of Trop2 expression and its prognostic value in gastric cancer (GC), particularly in Chinese populations. We analyzed Trop2 expression in GC tissues collected from Chinese GC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry on tissue microarrays were performed to assess levels of Trop2 mRNA and protein in GC, and correlations between Trop2 expression and clinical characteristics and prognosis were analyzed. Trop2 expression was higher in GC tissues than in neighboring non-tumor tissues. Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection. GC patients with high Trop2 expression also had poor overall survival rates. These data suggest Trop2 is a useful prognostic biomarker for GC.


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