Oncotarget

Research Papers:

Prognostic value of LAMP3 and TP53 overexpression in benign and malignant gastrointestinal tissues

Rongwei Sun, Xudong Wang, Huijun Zhu, Haijun Mei, Wei Wang, Shu Zhang and Jianfei Huang _

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Oncotarget. 2014; 5:12398-12409. https://doi.org/10.18632/oncotarget.2643

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Abstract

Rongwei Sun1,2,*, Xudong Wang3,*, Huijun Zhu1, Haijun Mei2, Wei Wang1, Shu Zhang1 and Jianfei Huang1

1 Department of Pathology, Nantong University Affiliated Hospital, Nantong, Jiangsu, China

2 Department of General Surgery, Nantong University Affiliated Hospital, Nantong, Jiangsu, China

3 Department of Laboratory Medicine, Nantong University Affiliated Hospital, Nantong, Jiangsu, China

* These authors contributed equally to this work

Correspondence:

Jianfei Huang, email:

Keywords: LAMP3, TP53, Prognosis, Gastrointestinal cancer

Received: September 09, 2014 Accepted: October 28, 2014 Published: October 28, 2014

Abstract

Lysosomal associated membrane protein 3 (LAMP3) is a newly identified tumor-specific protein. It is a downstream target gene of tumor suppressor TP53 and its expression has been associated with hypoxia-induced metastasis and poor overall survival in cervical and breast cancers. However, little is known of LAMP3 protein expression in gastrointestinal cancer and its prognostic value. We determined protein expression of LAMP3 and TP53 in both gastric (n=750) and colorectal (n=479) tissues by immunohistochemistry analysis on tissue microarray (TMA), their expression was correlated with patients’ clinical parameters. LAMP3 and TP53 protein expression was significantly higher in cancerous tissues compared to normal and benign tissues. In both gastric and colorectal cancers, high LAMP3 protein expression (LAMP3+) was significantly associated with tumor stage (P=0.014 and P<0.001). No correlation between LAMP3 and TP53 expression was observed. Patients with high LAMP3 expression but not high TP53 expression had a poor overall survival (for gastric cancer P<0.001, CI: 1.762-4.567; for colorectal cancer P=0.036, CI: 1.062-5.980). Our data suggest that epithelial LAMP3 expression is an independent prognostic marker for gastrointestinal cancer.


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