Oncotarget

Research Papers:

Dietary energy balance modulates ovarian cancer progression and metastasis

Zaid Al-Wahab, Calvin Tebbe, Jasdeep Chhina, Sajad A. Dar, Robert T. Morris, Rouba Ali-Fehmi, Shailendra Giri, Adnan R. Munkarah and Ramandeep Rattan _

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Oncotarget. 2014; 5:6063-6075. https://doi.org/10.18632/oncotarget.2168

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Abstract

Zaid Al-Wahab1, Calvin Tebbe2, Jasdeep Chhina2, Sajad A. Dar2, Robert T. Morris1, Rouba Ali-Fehmi3, Shailendra Giri4, Adnan R. Munkarah2 and Ramandeep Rattan2

1 Division of Gynecology Oncology, Wayne State University, Detroit, MI

2 Department of Women’s Health, Gynecology Oncology, Henry Ford Hospital, Detroit, MI

3 Department of Pathology, Karmanos Cancer Institute, Wayne State Univeristy, Detroit, MI

4 Department of Neurology, Henry Ford Hospital, Detroit, MI

Correspondence:

Ramandeep Rattan, email:

Keywords: : ovarian cancer, energy balance, calorie restriction, high energy diet, AMPK, SIRT1, mTOR

Received: June 10, 2014 Accepted: July 4, 2014 Published: July 5, 2014

Abstract

A high energy balance, or caloric excess, accounts as a tumor promoting factor, while a negative energy balance via caloric restriction, has been shown to delay cancer progression. The effect of energy balance on ovarian cancer progression was investigated in an isogeneic immunocompetent mouse model of epithelial ovarian cancer kept on a regimen of regular diet, high energy diet (HED) and calorie restricted diet (CRD), prior to inoculating the animals intraperitoneally with the mouse ovarian surface epithelial ID8 cancer cells. Tumor evaluation revealed that mice group on HED displayed the most extensive tumor formation with the highest tumor score at all organ sites (diaphragm, peritoneum, bowel, liver, kidney, spleen), accompanied with increased levels of insulin, leptin, insulin growth factor-1 (IGF-1), monocyte chemoattractant protein-1 (MCP-1), VEGF and interleukin 6 (IL-6). On the other hand, the mice group on CRD exhibited the least tumor burden associated with a significant reduction in levels of insulin, IGF-1, leptin, MCP-1, VEGF and IL-6. Immunohistochemistry analysis of tumors from HED mice showed higher activation of Akt and mTOR with decreased adenosine monophosphate activated kinase (AMPK) and SIRT1 activation, while tumors from the CRD group exhibited the reverse profile. In conclusion, ovarian cancer growth and metastasis occurred more aggressively under HED conditions and was significantly curtailed under CRD. The suggested mechanism involves modulated secretion of growth factors, cytokines and altered regulation of AMPK and SIRT1 that converges on mTOR inhibition. While the role of a high energy state in ovarian cancer has not been confirnmed in the literature, the current findings support investigating the potential impact of diet modulation as adjunct to other anticancer therapies and as possible individualized treatment strategy of epithelial ovarian cancer.


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