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Research Papers:

Forensic efficiency and genetic variation of 30 InDels in Vietnamese and Nigerian populations

Weian Du, Zhiyong Peng, Chunlei Feng, Bofeng Zhu, Bangchao Wang, Yue Wang, Liu Chao _ and Ling Chen

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Oncotarget. 2017; 8:88934-88940. https://doi.org/10.18632/oncotarget.21494

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Abstract

Weian Du1,4,*, Zhiyong Peng2,*, Chunlei Feng1,*, Bofeng Zhu1, Bangchao Wang4, Yue Wang1, Chao Liu1,3 and Ling Chen1

1School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China

2Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China

3Guangzhou Forensic Science Institute, Guangdong Province Key Laboratory of Forensic Genetics, Guangzhou 510030, China

4Guangdong Homy Genetics Incorporation, Foshan 512000, China

*These authors have contributed equally to this work

Correspondence to:

Chao Liu, email: liuchaogzf@163.com

Ling Chen, email: lingpzy@163.com

Keywords: insertion/deletion loci, DIPplex, Vietnamese, Nigerian, forensic genetics

Received: May 04, 2017     Accepted: August 23, 2017     Published: October 04, 2017

ABSTRACT

Insertion/deletion polymorphisms (InDels) are ubiquitous diallelic genetic markers that have drawn increasing attention from forensic researchers. Here, we investigated 30 InDel loci in Vietnamese and Nigerian populations and evaluated their usefulness in forensic genetics. The polymorphic information content of these populations ranged, respectively, from 0.164 to 0.375 and from 0.090 to 0.375 across loci. After Bonferroni correction, no significant deviation from Hardy-Weinberg equilibrium was found, except for HLD97 in the Nigerian population. The cumulative power of exclusion for all 30 loci in the Vietnamese and Nigerian populations was 0.9870 and 0.9676, respectively, indicating that this InDel set is not suitable for paternity testing in these populations, but could be included as a supplement. For the Vietnamese and the Nigerian populations, the mean observed heterozygosity was 0.5917 and 0.6268, and the combined discrimination power of the 30 loci was 0.9999999999767 and 0.9999999999603, respectively. These findings indicated that these InDels may be suitable for personal forensic identification in the studied populations. The results of DA distance, phylogenetic tree, principal component, and cluster analyses were consistent and indicated a clear pattern of regional distribution. Moreover, the Vietnamese population was shown to have close genetic relationships with the Guangdong Han and Shanghai Han populations.


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