Association of FOXF2 gene polymorphisms with ischemic stroke in Chinese Han population
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Chang-He Shi1,*, Mi-Bo Tang1,*, Shao-Hua Li1,*, Zhi-Jie Wang1, Xin-Jing Liu1, Lu Zhao1, Yuan Gao1, Yu-Sheng Li1, Shi-Lei Sun1, Jun Wu1, Bo Song1 and Yu-Ming Xu1
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, Henan, China
*These authors contributed equally to this work
Yu-Ming Xu, email: [email protected]
Bo Song, email: [email protected]
Keywords: FOXF2, single nucleotide polymorphism, ischemic stroke, large artery atherosclerotic stroke, small vessel disease stroke
Received: June 21, 2017 Accepted: September 08, 2017 Published: September 23, 2017
Recently, a novel locus at chromosome 6p25 (rs12204590, near FOXF2) associated with an increased risk of stroke in European populations was identified. However, whether polymorphisms in FOXF2 are also associated with the incidence of ischemic stroke in other populations remains unknown. In this case-control study, 803 Chinese Han patients with ischemic stroke and 803 matched control individuals were enrolled. Four tag SNPs and rs12204590 located in or near FOXF2 were selected, and the associations between genotypes/alleles and ischemic stroke were analyzed. In our study, we did not detect an association between the previously reported locus rs12204590 and ischemic stroke. By the genotype analysis, a novel SNP rs1711972, near FOXF2, was observed to be associated with an increased risk of ischemic stroke(CA genotype, adjusted OR = 1.35; 95% CI, 1.07 to 1.70), but not significantly after Bonferroni corrections for multiple tests. However, in the subgroup analysis, we discovered that rs1711972 was associated with an increased risk of large-artery atherosclerotic stroke in the additive model (P = 0.020; CA genotype, adjusted OR = 1.50; 95%CI, 1.09 to 2.07) and dominant model (P = 0.010; OR = 1.47; 95%CI, 1.09 to 1.99). Collectively, these results indicate that a novel SNP near FOXF2 may influence the risk of large-artery atherosclerotic stroke in Chinese Han population.
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