FcGBP was upregulated by HPV infection and correlated to longer survival time of HNSCC patients
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Yating Wang1,*, Yan Liu1,*, Huiqiao Liu1,*, Qingan Zhang2, Hongyan Song3, Jianliang Tang4, Jiangtao Fu1 and Xiaofei Wang1
1Department of Otolaryngology Head and Neck Surgery, Lishui People’s Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China
2Department of Clinical Laboratory, The Central Hospital of Linyi, Yishui, Shandong, China
3Department of Otolaryngology, Yunhe People’s Hospital, Yunhe, Zhejiang, China
4Department of Psychiatry, Tongxiang First People’s Hospital, Tongxiang, Zhejiang, China
*These authors have contributed equally to this work
Xiaofei Wang, email: [email protected]
Jiangtao Fu, email: [email protected]
Jianliang Tang, email: [email protected]
Keywords: FcGBP, HPV, HNSCC, TGF-β, migration
Received: July 12, 2017 Accepted: August 09, 2017 Published: September 23, 2017
FcGBP was normally found in intestinal and colonic epithelia, gallbladder, cystic duct, bronchus, submandibular gland, cervix uteri and in fluids secreted by these cells in humans, and was down-regulated during colon carcinogenesis. We found FcGBP gene expression was decreased in HNSCC tissues compared to surgical safety border tissues while TGF-β expression level increased in HNSCC tissues, and higher FcGBP expression level was correlated to longer OS time of HNSCC patients. FcGBP expression level was higher in HPV-positive HNSCC tissues compared to HPV-negative HNSCC tissues, while TGF-β expression level was lower in HPV-positive HNSCC tissues. Gene expression level of FcGBP and TGF-β was negatively correlated in HNSCC tissues. FcGBP expression level increased after HPV E6 overexpression in HPV-negative HNSCC cells, and TGF-β could inhibit the up-regulation of FcGBP after HPV E6 or FcGBP overexpression in HPV-negative HNSCC cells. The migration capability was inhibited after FcGBP overexpression, and TGF-β could counteract the inhibition of migration caused by FcGBP overexpression. FcGBP gene expression level was correlated to the expression levels of EMT markers. In conclusion, FCGBP expression was upregulated by HPV infection while inhibited by TGF-β, and was correlated to the prognosis of HNSCC patients.
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