Oncotarget

Meta-Analysis:

Prognostic value of lncRNAs in lung carcinoma: a meta-analysis

Fan Fan, Zhengqiu Zhu, Chao Gao, Yun Liu, Baoqing Wang, Ziquan Wang and Jifeng Feng _

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Oncotarget. 2017; 8:83292-83305. https://doi.org/10.18632/oncotarget.21096

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Abstract

Fan Fan1,2, Zhengqiu Zhu3, Chao Gao3, Yun Liu1, Baoqing Wang2, Ziquan Wang2 and Jifeng Feng1

1Department of Chemotherapy, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210009, China

2Department of Chemotherapy, The No.2 Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China

3Department of Chemotherapy, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China

Correspondence to:

Jifeng Feng, email: [email protected]

Keywords: lncRNA, lung cancer, prognosis

Received: July 06, 2017     Accepted: August 29, 2017     Published: September 20, 2017

ABSTRACT

Many different long non-coding RNAs (lncRNAs) have been reported to be abnormally expressed in lung carcinoma and may thus serve as prognostic biomarkers for this disease. We conducted this meta-analysis, which included a total of 30 studies identified via searches of PubMed, Embase, Medline, and Web of Science and included 2912 patients from China (28), Germany (1), and Japan (1), to investigate the prognostic value of different lncRNAs in lung carcinoma. The results revealed that lncRNA transcription levels were significantly associated with overall survival in lung cancer patients (HR:1.46, 95% CI: 1.16–1.83, P = 0.000). However, lncRNA transcription levels were not associated with progression-free survival (PFS) (HR: 1.55, 95% CI: 0.50–4.80, P = 0.449). Further analysis showed that high lncRNA transcription levels were significantly associated with tumour-node-metastasis (TNM) stage (III/IV vs I/II: RR = 1.339, 95% CI: 1.046–1.716, P = 0.012), lymph node metastasis (positive vs negative: RR = 1.442, 95% CI: 1.103–1.885, P = 0.007), and distant metastasis (yes vs no: RR = 3.187,95% CI: 1.393–7.294, P = 0.006). Taken together, the results of our present meta-analysis revealed that lncRNAs may be useful prognostic markers for lung carcinoma and may also have value as biomarkers for TNM stage, lymph node metastasis and distant metastasis.


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