Research Papers:

MAPK, NFκB, and VEGF signaling pathways regulate breast cancer liver metastasis

Xinhua Chen _, Zhihong Zheng, Limin Chen and Hongyu Zheng

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Oncotarget. 2017; 8:101452-101460. https://doi.org/10.18632/oncotarget.20843

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Xinhua Chen1, Zhihong Zheng2, Limin Chen1 and Hongyu Zheng1

1Department of Medical Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian, China

2Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

Correspondence to:

Xinhua Chen, email: [email protected]

Keywords: breast cancer; metastasis; liver; microarray; interaction network

Received: April 23, 2017    Accepted: August 07, 2017    Published: September 12, 2017


In this study, we investigated the molecular pathways regulating breast cancer liver metastasis. We identified 48 differentially expressed genes (4 upregulated and 44 downregulated) by analyzing microarray dataset GSE62598 from Gene Expression Omnibus (GEO). We constructed a genetic interaction network with 84 nodes and 237 edges using the String consortium database. The network was reliably robust with a clustering coefficient (cc) of 0.598 and protein-protein interaction (PPI) enrichment p value of zero. Using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases, we identified MAPK, NFκB and VEGF signaling pathways as the most critical pathways regulating breast cancer liver metastasis. These results indicate that the distinct breast cancer metastatic stages, including dissemination from the primary breast tumor, transit through the vasculature, and survival and proliferation in the liver, are regulated by the MAPK, NFκB, and VEGF signaling pathways.

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