MMP9 polymorphism is associated with susceptibility to non-traumatic osteonecrosis of femoral head in a Chinese Han population
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Yuan Liu1,2,*, Yanfei Jia2,*, Yuju Cao3, Yan Zhao2, Jieli Du1,2, Feimeng An1,2, Yuxin Qi1,2, Xue Feng4, Tianbo Jin5, Jianping Shi6 and Jianzhong Wang2
1Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
2Department of Orthopedics and Traumatology, The Second Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, China
3Zhengzhou Traditional Chinese Medicine Traumatology Hospital, Zhengzhou, Henan, China
4College of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia, China
5The College of Life Sciences Northwest University, Xi'an, Shaanxi, China
6Department of TCM Diagnoses, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
*These authors have contributed equally to this work and should be considered co-first authors
Jianping Shi, email: [email protected]
Jianzhong Wang, email: [email protected]
Keywords: MMP9, MMP2, non-traumatic osteonecrosis of the femoral head, single nucleotide polymorphisms, association study
Received: February 28, 2017 Accepted: June 30, 2017 Published: August 24, 2017
Non-traumatic osteonecrosis of femoral head (ONFH) is an orthopedic refractory disease with escalating morbidity in Chinese Han population. In our case-control study, we examined eight previously identified MMP9 single-nucleotide polymorphisms (SNPs) in 585 non-traumatic ONFH patients and 507 healthy individuals from northern China to determine whether these SNPs associated with the risk of developing non-traumatic ONFH. Genetic model and haplotype analyses were used to evaluate the association between SNPs and non-traumatic ONFH. MMP9 rs2274755 (OR, 0.740; 95% CI, 0.578-0.949; p = 0.017) was associated with a reduced risk of non-traumatic ONFH. After adjusting for age and gender, the logistic regression results showed that rs2274755 associated with a lower risk of non-traumatic ONFH in the dominant (OR=0.71, 95% CI: 0.54-0.94, p=0.016), overdominant (OR=0.73, 95% CI: 0.55-0.96, p=0.026) and log-additive (OR=0.74740; 95% CI, 0.578-0.949; p=0.017) models. In addition, the “TGC” haplotype of rs2274755 was associated with a 0.79-fold decrease in risk while the “CTC” haplotype associated with a 0.65-fold decrease risk of the non-traumatic ONFH. These results provide evidence that the MMP9 SNP at the rs2274755 locus is associated with a decreased risk of non-traumatic ONFH in a Chinese Han population.
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