SOCS molecules: the growing players in macrophage polarization and function

Dexi Zhou, Lu Chen, Kui Yang, Hui Jiang, Wenke Xu and Jiajie Luan _

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Oncotarget. 2017; 8:60710-60722. https://doi.org/10.18632/oncotarget.19940

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Dexi Zhou1,2,*, Lu Chen1,2,*, Kui Yang1,2, Hui Jiang1,2, Wenke Xu1,2 and Jiajie Luan1,2

1Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui Province, China

2Laboratory of Clinical Pharmacy, Wannan Medical College, Wuhu, Anhui Province, China

*These authors have contributed equally to this work

Correspondence to:

Jiajie Luan, email: [email protected]

Dexi Zhou, email: [email protected]

Keywords: macrophage polarization, cytokines signaling, suppressors of cytokine signaling

Received: June 22, 2017     Accepted: July 25, 2017     Published: August 04, 2017


The concept of macrophage polarization is defined in terms of macrophage phenotypic heterogeneity and functional diversity. Cytokines signals are thought to be required for the polarization of macrophage populations toward different phenotypes at different stages in development, homeostasis and disease. The suppressors of cytokine signaling family of proteins contribute to the magnitude and duration of cytokines signaling, which ultimately control the subtle adjustment of the balance between divergent macrophage phenotypes. This review highlights the specific roles and mechanisms of various cytokines family and their negative regulators link to the macrophage polarization programs. Eventually, breakthrough in the identification of these molecules will provide the novel therapeutic approaches for a host of diseases by targeting macrophage phenotypic shift.

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