Decoding the full picture of Raf1 function based on its interacting proteins
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Ying Huang1,2, Xiao-Xi Guo1, Bing Han3, Xu-Min Zhang4, Su An1, Xin-Yu Zhang1, Yang Yang1, Ying Liu1, Qian Hao1 and Tian-Rui Xu1
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
2Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, China
3Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, China
4State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, China
Tian-Rui Xu, email: [email protected]
Keywords: Raf1, interacting protein, cancer, cell signaling, oncological target
Received: March 01, 2017 Accepted: June 18, 2017 Published: July 18, 2017
Raf1 is a member of the Raf kinase family and regulates many fundamental cell processes, including proliferation, differentiation, apoptosis, motility, and metabolism. However, the functions of Raf1 have not been completely elucidated. To better understand Raf1 function, we investigated the proteins that interacted with Raf1. We identified 198 Raf1 interacting proteins and our data suggested that Raf1 may regulate cell processes through these interactions. These interaction partners were involved in all ten hallmarks of cancer, suggesting that Raf1 is involved in different aspects of carcinogenesis. In addition, we showed that Raf1 interacting proteins were enriched in six signaling pathways and many human diseases. The interaction partners identified in this study may represent oncological candidates for future investigations into Raf1 function. Our findings have provided an overview of Raf1 function from a systems biology perspective.
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