Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression
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Hao Zhang1,*, Guangchao Wang1,*, Chen Ding1,*, Peng Liu2,*, Renkai Wang1, Wenbin Ding1, Dake Tong1, Dajiang Wu1, Cheng Li1, Qiang Wei1, Xin Zhang1, Di Li1, Peizhao Liu1, Haochen Cui1, Hao Tang1 and Fang Ji1
1Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China
2Department of General Sugery, Changhai Hospital, Second Military Medical University, Shanghai, China
*These authors have contributed equally to this work
Fang Ji, email: [email protected]
Hao Tang, email: [email protected]
Keywords: circRNA, circUBAP2, osteosarcoma, miR-143, Bcl-2
Received: March 24, 2017 Accepted: May 23, 2017 Published: June 27, 2017
Deregulated expression of circular RNA (circRNA) has been determined to be important in carcinogenesis and progression; however, in the most common type of primary malignant bone tumor osteosarcoma, the roles of circRNA in cancer development still remain to be elucidated. Here, we found that circRNA UBAP2 (circUBAP2) expression is significantly increased in human osteosarcoma tissues as compared to those in matched controls. Increased circUBAP2 expression was significantly correlated with human osteosarcoma progression and prognosis. Furthermore, increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both in vitro and in vivo. Mechanistically, circUBAP2 was found to inhibit the expression of microRNA-143 (miR-143), thus enhancing the expression and function of anti-apoptotic Bcl-2, which is a direct target of miR-143. Together, our results suggest the roles of circUBAP2 in osteosarcoma development and implicate its potential in prognosis prediction and cancer therapy.
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