Oncotarget

Research Papers:

Clinic characteristics of psoriasis in China: a nationwide survey in over 12000 patients

Kun Chen, Gang Wang, Hongzhong Jin, Jinhua Xu, Xuejun Zhu, Min Zheng and Heng Gu _

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Oncotarget. 2017; 8:46381-46389. https://doi.org/10.18632/oncotarget.18453

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Abstract

Kun Chen1, Gang Wang2, Hongzhong Jin3, Jinhua Xu4, Xuejun Zhu5, Min Zheng6 and Heng Gu1

1Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing, Jiangsu, China

2Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi, China

3Peking Union Medical Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking, China

4Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China

5Department of Dermatology, Peking University First Hospital, Peking, China

6Department of Dermatology, Second Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China

Correspondence to:

Heng Gu, email: [email protected]

Min Zheng, email: [email protected]

Keywords: psoriasis, epidemiology, phenotype, Chinese Han

Received: November 17, 2016     Accepted: April 29, 2017     Published: June 12, 2017

ABSTRACT

Psoriasis is a worldwide chronic inflammatory disease, involving both skin and joints. In order to characterize psoriasis in Han Chinese population, we conducted this nationwide prospective and hospital based survey, in which 56 hospitals with departments of dermatology participated, located in 33 cities across China. A total of 12,031 outpatients with psoriasis were registered during 2009 to 2010, which the data was collected by standard questionnaires. The main data acquisition included demographics, family history, disease status and other comorbidities. Physical and dermatological examination, including body surface area (BSA) and psoriasis area severity index (PASI) were applied to evaluate the disease severity. Descriptive statistics, 2 tailed t-test and chi-square test were used appropriately for the statistical analysis. From the study, we found that the male and female ratio of the patients was 1.49:1. Mean age of onset was 30.2 ± 14.5 years for males and 27.1 ± 15.6 years for females (P < 0.05). Scalp was the most common onset site (52.8%), The mean PASI was 18.70 ± 10.01, indicating that most patients presenting at the hospitals had moderate-to-severe psoriasis and the majority was psoriasis vulgaris (96.5%). Among 12,031 patients, 23.1% had a family history of psoriasis,16.1% had comorbidities, and 29.9% had nail changes. The most important aggravation factor was season change (60.2%), followed by psychological stress (34.5%), and there significant differences between genders on trigger factors. In conclusion, this study characterizing psoriasis in Han Chinese population, could be used as basic data for future study.


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