Research Perspectives:

PAFc, a Key Player in MLL-rearranged Leukemogenesis

Jiaying Tan, Andrew G. Muntean and Jay L. Hess _

PDF  |  HTML  |  How to cite

Oncotarget. 2010; 1:461-465. https://doi.org/10.18632/oncotarget.181

Metrics: PDF 2632 views  |   HTML 3905 views  |   ?  


Received: September 8, 2010, Accepted: October 5, 2010, Published: October 5, 2010

Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLL-rearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 181