Research Papers:

Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction

Pengfei Hu, Tao Dai, Weiwei Yu, Ying Luo and Shuwei Huang _

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Oncotarget. 2017; 8:52594-52603. https://doi.org/10.18632/oncotarget.17529

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Pengfei Hu1,*, Tao Dai2,*, Weiwei Yu1, Ying Luo1 and Shuwei Huang1

1Department of Cardiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

2Department of Cardiology, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China

*These authors contributed equally to this work

Correspondence to:

Shuwei Huang, email: [email protected]

Keywords: ICAM-1, rs5498, myocardial infarction, meta-analysis

Received: March 20, 2017     Accepted: April 17, 2017     Published: April 29, 2017


Several studies addressed the association between Intercellular adhesion molecule 1 (ICAM-1) rs5498 polymorphism and Myocardial Infarction (MI) risk. However, they addressed conflicting findings. Therefore, the aim of this study was to explore whether ICAM-1 gene rs5498 polymorphism plays an important role in modifying the risk of MI. A meta-analysis was conducted on the association between ICAM-1 rs5498 polymorphism and MI. 12 eligible studies involving 1,696 cases and 3,039 controls were included in the meta-analysis. Meta-analysis revealed that ICAM-1 rs5498 polymorphism showed a strongly positive correlation with MI and could be viewed as a protective factor for MI. Furthermore, subgroup analysis according to ethnicity indicated that ICAM-1 rs5498 polymorphism decreased the risk of MI among Caucasian and Asian populations. In conclusion, ICAM-1 rs5498 polymorphism was associated with the decreased risk of MI. Larger sample size studies with more diverse ethnic populations are needed to confirm these findings.

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