Oncotarget

Clinical Research Papers:

Different patterns of age-related central olfactory decline in men and women as quantified by olfactory fMRI

Brittany Martinez, Prasanna Karunanayaka, Jianli Wang, Michael J. Tobia, Megha Vasavada, Paul J. Eslinger and Qing X. Yang _

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Oncotarget. 2017; 8:79212-79222. https://doi.org/10.18632/oncotarget.16977

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Abstract

Brittany Martinez1, Prasanna Karunanayaka1, Jianli Wang1, Michael J. Tobia1, Megha Vasavada1, Paul J. Eslinger1,2 and Qing X. Yang1,3

1 Department of Radiology, Center for NMR Research, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, PA, USA

2 Department of Neurology, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, PA, USA

3 Department of Neurosurgery, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, PA, USA

Correspondence to:

Qing X. Yang, email:

Keywords: neuroimaging, olfaction, fMRI, sex differences, presbyosmia

Received: December 26, 2016 Accepted: March 02, 2017 Published: April 08, 2017

Abstract

Age-related olfactory decline, or presbyosmia, is a prevalent condition with potentially devastating consequences on both quality of life and safety. Despite clear evidence for this decline, it is unknown whether presbyosmia is sex-dependent and also whether it is due to central or peripheral olfactory system deterioration. Therefore, the goals of this study were to investigate the neurofunctional substrate of olfactory decline and examine its relationship to age and sex in thirty-seven (18 women, 19 men) healthy older participants using olfactory functional MRI (fMRI). The olfactory fMRI paradigm utilized unique odor+visual and visual-only conditions to contrast peripheral-to-central and central-to-central olfactory processing, respectively. Age was negatively correlated with fMRI activation in olfactory-related regions. Significant aging effects were identifiable in male participants in all target regions. Female participants, however, showed a different pattern of functional decline. Extended unified structural equation modeling (euSEM) analysis revealed that the effective functional connectivity profile was drastically different between male and female participants, with females manifesting a top-down mechanism to offset age-related olfactory activation decline. Our results support the hypotheses that the central olfactory system is involved in age-related olfactory decline, and that resilience to age-related olfactory decline in women may be due to their profuse olfactory network effective connectivity.


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