Tea consumption and the risk of biliary tract cancer: a systematic review and dose-response meta-analysis of observational studies

Jianping Xiong, Jianzhen Lin, Anqiang Wang, Yaqin Wang, Ying Zheng, Xinting Sang, Yiyao Xu, Xin Lu and Haitao Zhao _

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Oncotarget. 2017; 8:39649-39657. https://doi.org/10.18632/oncotarget.16963

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Jianping Xiong1,*, Jianzhen Lin1,*, Anqiang Wang1,*, Yaqin Wang2, Ying Zheng3, Xinting Sang1, Yiyao Xu1, Xin Lu1, Haitao Zhao1

1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

2Department of Interventional Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China

3State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau SAR, China

*These authors contributed equally to this work

Correspondence to:

Yiyao Xu, email: [email protected]

Xin Lu, email: [email protected]

Haitao Zhao, email: [email protected]

Keywords: tea, biliary tract cancer, cholangiocarcinoma, bile duct cancer

Received: January 09, 2017     Accepted: March 29, 2017     Published: April 08, 2017


Recent studies have shown that tea consumption is associated with the reduced incidence of some types of cancer, possibly including biliary tract cancer. However, the epidemiological evidences for the association with risk of biliary tract cancer are contradictory. Thus, we performed meta-analysis of published observational studies to assess the association between tea consumption and risk of biliary tract cancer. Relevant studies were identified by searching PubMed, EMBASE, and ISI Web of Science published before October 2016. The Newcastle–Ottawa Scale was used to evaluate the quality of included studies, and publication bias was evaluated using funnel plots, and Begg’s and Egger’s tests. This meta-analysis includes eight studies comprising 18 independent reports. The incidence of biliary tract cancer reduced about 34% (significantly) for tea intake group in comparison with never intake group (summary odds ratio [OR] = 0.66; 95% confidence interval [CI] = 0.48–0.85). Additionally, an inverse relationship between tea intake and risk of biliary tract cancer was statistically significant in women (OR = 0.65; 95 % CI = 0.47–0.83), but not in men (OR = 0.86; 95% CI = 0.58–1.13). Dose– response analysis indicated that the risk of biliary tract cancer decreased by 4% with each additional cup of tea one day (relative risk [RR] = 0.96, 95% CI = 0.93–0.98, p = 0.001). In summary, tea intake is associated with decreased risk of biliary tract cancer, especially for women.

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