Research Papers:

Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

Xia Zhang, Qingyan Chi and Zhenhua Zhao _

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Oncotarget. 2017; 8:51058-51065. https://doi.org/10.18632/oncotarget.16918

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Xia Zhang1, Qingyan Chi2 and Zhenhua Zhao3

1Department of Respiratory Internal Medicine, The People’s Hospital of Linyi City, Shandong, China

2Department of Neonatal, The People’s Hospital of Linyi City, Shandong, China

3Department of Infectious Diseases, The People’s Hospital of Linyi City, Shandong, China

Correspondence to:

Zhenhua Zhao, email: [email protected]

Keywords: long non-coding RNA, SPRY4-IT1, lung adenocarcinoma, prognosis

Received: February 09, 2017    Accepted: March 14, 2017    Published: April 07, 2017


Long non-coding RNAs (lncRNAs) play important role in a variety of biological processes, and are tightly associated with tumorigenesis and cancer prognosis. However, the potential power of lncRNA signatures in predicting survival of patients with lung adenocarcinoma (LUAD) has not been investigated. Here, we identified a four-lncRNA signature (SPRY4-IT1, LINC00941,GPR158-AS1 and KCNK15-AS1) displaying prognostic values for LUAD using The Cancer Genome Atlas (TCGA) dataset. Based on the four-lncRNA signature, the LUAD patients can be classified into high-risk and low-risk groups with significantly different survival. We further validated the expression of SPRY4-IT1 in LUAD tissues and corresponding normal lung tissues using quantitative real-time PCR in Chinese LUAD patients. The results showed that SPRY4-IT1 was significantly up-regulated in LUAD tissues. Further analysis indicated that LUAD patients with high SPRY4-IT1 expression have significantly poorer overall survival in Chinese LUAD patients. Moreover, knock-down of SPRY4-IT1 can inhibit the lung cancer cell migration and invasion. The present work indicated that SPRY4-IT1 may play a pivotal role in promoting tumor migration and invasion in LUAD. Our work implicates the promising effect of SPRY4-IT1 on the prognosis of LUAD.

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