Chronic grouped social restriction triggers long-lasting immune system adaptations
Metrics: PDF 1218 views | HTML 2171 views | ?
Rui Tian1,2,*, Gonglin Hou1,*, Liuwei Song3, Jianming Zhang1, Ti-Fei Yuan4,5,6
1Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, China
2State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
3National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China
4School of Psychology, Nanjing Normal University, Nanjing, China
5Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China
6State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong
*The authors contributed equally to this work
Gonglin Hou, email: email@example.com
Ti-Fei Yuan, email: firstname.lastname@example.org
Keywords: chronic stress, cytokines, chemokines, social restriction, human
Received: February 08, 2017 Accepted: March 28, 2017 Published: April 05, 2017
Chronic stress triggers rigorous psychological and physiological changes, including immunological system adaptations. However, the effects of long-term social restriction on human immune system have not been investigated. The present study is to investigate the effect of chronic stress on immune changes in human blood, with the stress stimuli controlled.10 male volunteers were group isolated from the modern society in a 50-meter-square room for 150 days, with enriched nutrition and good living conditions provided. Serum examination of immune system markers demonstrated numerous changes in different aspects of the immune functions. The changes were observed as early as 30 days and could last for another 150 days after the termination of the restriction period (300 days’ time point). The results strongly argued for the adaptation of immunological system under chronic social restriction stress in adult human, preceding a clear change in psychological conditions. The changes of these immune system factors could as well act as the serum biomarkers in clinical early-diagnosis of stress-related disorders.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.