Research Papers:

Use of acetaminophen and risk of endometrial cancer: evidence from observational studies

Yuan-Yuan Ding, Peng Yao _, Surya Verma, Zhen-Kai Han, Tao Hong, Yong-Qiang Zhu and Hong-Xi Li

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Oncotarget. 2017; 8:34643-34651. https://doi.org/10.18632/oncotarget.16663

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Yuan-Yuan Ding1, Peng Yao1, Surya Verma2, Zhen-Kai Han1, Tao Hong1, Yong-Qiang Zhu1, Hong-Xi Li1

1Department of Pain Management, Shengjing Hospital of China Medical University, Shenyang, China

2School of Undergraduate, China Medical University, Shenyang, China

Correspondence to:

Peng Yao, email: [email protected]

Keywords: acetaminophen, endometrial cancer, meta-analysis, observational study, systematic review

Received: February 22, 2017     Accepted: March 21, 2017     Published: March 29, 2017


Previous meta-analyses suggested that aspirin was associated with reduced risk of endometrial cancer. However, there has been no study comprehensively summarize the evidence of acetaminophen use and risk of endometrial cancer from observational studies. We systematically searched electronic databases (PubMed , EMBASE, Web of Science, and Cochrane Library) for relevant cohort or case-control studies up to February 28, 2017. Two independent authors performed the eligibility evaluation and data extraction. All differences were resolved by discussion. A random-effects model was applied to estimate summary relative risks (RRs) with 95% CIs. All statistical tests were two-sided. Seven observational studies including four prospective cohort studies and three case-control studies with 3874 endometrial cancer cases were included for final analysis. Compared with never use acetaminophen, ever use this drug was not associated with risk of endometrial cancer (summarized RR = 1.02; 95% CI: 0.93−1.13, I2 = 0%). Similar null association was also observed when compared the highest category of frequency/duration with never use acetaminophen (summarized RR = 0.88; 95% CI: 0.70−1.11, I2 = 15.2%). Additionally, the finding was robust in the subgroup analyses stratified by study characteristics and adjustment for potential confounders and risk factors. There was no evidence of publication bias by a visual inspection of a funnel plot and formal statistical tests. In summary, the present meta-analysis reveals no association between acetaminophen use and risk of endometrial cancer. More large scale prospective cohort studies are warranted to confirm our findings and carry out the dose-response analysis of aforementioned association.

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