Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis
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Xue-Feng Li1,*, Xin-Hai Yin2,*, Jun-Wei Cai1,*, Ming-Ju Wang3, Yu-Qin Zeng1, Min Li1, Yu-Ming Niu1,4 and Ming Shen5
1Department of Endocrinology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
2Department of Oral and Maxillary Surgery, Gui Zhou Provincial People’s Hospital, Guiyang 550000, China
3Information Resources, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
4Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
5Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China
*These authors contributed equally to this work
Yu-Ming Niu, email: [email protected]
Ming Shen, email: [email protected]
Keywords: H19, polymorphism, cancer, meta-analysis
Received: August 15, 2016 Accepted: March 19, 2017 Published: March 29, 2017
Previous epidemiological research suggests polymorphisms in long non-coding RNA (lncRNA) H19 are associated with an increased risk of cancer, but the results are inconsistent. We therefore conducted a meta-analysis to more accurately determine the association between lncRNA H19 polymorphisms and cancer risk. The PubMed, Embase, and Science Citation Index online databases were searched and 11 relevant studies involving a total of 33,209 participants were identified. Odds ratios (ORs) and corresponding 95% confidence interval (CIs) from these studies were used to detect associations between H19 polymorphisms and cancer risk using five genetic models. The pooled result suggested that the rs2839698 G>A polymorphism was associated with digestive cancer risk in all five models. Moreover, a protective effect against cancer development was observed for the T allele variant of the rs2107425 C>T polymorphism, especially in Caucasian patient populations. No significant associations were found between lncRNA H19 rs217727 G>A polymorphism and cancer risk. In summary, the rs2839698 G>A and rs2107425 C>T polymorphisms in lncRNA H19 may therefore play opposing roles during cancer development, and their effects may vary depending on cancer type and patient ethnicity.
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