Research Papers:

Relationship of p73 gene polymorphism and additional gene-smoking and gene-obesity interaction with non-small cell lung cancer risk

Qiuge Wu, Yan Shi, Lulu Ge, Dongbo Ma, Hui Zhang and Jing Wang _

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Oncotarget. 2017; 8:34423-34428. https://doi.org/10.18632/oncotarget.16257

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Qiuge Wu1, Yan Shi1, Lulu Ge1, Dongbo Ma1, Hui Zhang1, Jing Wang1

1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Henan, China

Correspondence to:

Jing Wang, email: [email protected]

Keywords: non-small cell lung cancer, G4C14-to-A4T14, polymorphism, interaction, smoking

Received: October 09, 2016     Accepted: March 01, 2017     Published: March 16, 2017


Aim: The aim of this study was to investigate the impact of G4C14-to-A4T14 polymorphism within P73 gene and additional interactions with current smoking and obesity on non-small cell lung cancer (NSCLC) risk in a Chinese population.

Results: Logistic regression analysis showed a significant association between genotypes of the AT allele in G4C14-to-A4T14 and decreased NSCLC risk. NSCLC risk was significantly lower in carriers of the G4C14-to-A4T14- AT allele than those with GC/GC genotype (AT/AT + GC/AT versus GC/GC), adjusted OR (95%CI) = 0.68 (0.55–0.93). We also found that the OR (95%CI) was 1.88 (1.32-2.47) for current smokers compared with never smokers and 0.69 (0.40–0.95) for obese subjects compared to participants with normal BMI. Never smokers with AT/AT or GC/AT of the G4C14-to-A4T14 genotype have the lowest NSCLC risk compared with smokers with the GC/GC genotype after covariates adjustment, OR (95%CI) = 0.52 (0.26-0.87). Obese participants with G4C14-to-A4T14- AT/AT or GC/AT genotype have the lowest NSCLC risk compared with non- obese subjects with the GC/GC genotype after adjusting for covariates, OR (95% CI) = 0.56 (0.33–0.85).

Materials and Methods: A logistic regression model was used to examine the association between G4C14-to-A4T14 polymorphism and NSCLC, and its interaction with current smoking and obesity. The odds ratios (OR) and 95% confident intervals (95%CI) were calculated.

Conclusions: Our results support an important association between the G4C14-to-A4T14 and decreased NSCLC risk and additional impact of an interaction between G4C14-to-A4T14 and smoking or obesity on NSCLC risk.

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