Oncotarget

Clinical Research Papers:

Gap in gender parity: gender disparities in incidence and clinical impact of chronic total occlusion in non-infarct artery in patients with non-ST-segment elevation myocardial infarction and multivessel coronary artery disease

Mateusz Tajstra _, Michał Hawranek, Piotr Desperak, Aneta Ciślak and Mariusz Gąsior

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Oncotarget. 2017; 8:79137-79146. https://doi.org/10.18632/oncotarget.16134

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Abstract

Mateusz Tajstra1, Michał Hawranek1, Piotr Desperak1, Aneta Ciślak1 and Mariusz Gąsior1

1 Third Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland

Correspondence to:

Mateusz Tajstra, email:

Keywords: gender, sex, chronic total occlusion, non-ST-segment elevation myocardial infarction, percutaneous coronary intervention

Received: November 22, 2016 Accepted: March 03, 2017 Published: March 11, 2017

Abstract

A chronic total occlusion in a non-infarct-related artery is an independent predictor of mortality in non-ST elevation myocardial infarction. There are no mortality data about the impact of a chronic total occlusion in patients with non-ST elevation myocardial infarction according to gender. The purpose of this study was to evaluate the prevalence of the chronic total occlusion in in men and women and examine its impact on clinical outcomes. Data from consecutive patients with multivessel coronary artery disease treated in a high-volume center between 2006 and 2012 were included in a prospective registry and divided according to gender and the presence of chronic total occlusion. All of the analyzed patients were followed up for at least 24 months, with all-cause mortality defined as the primary endpoint.

Among the 515 patients who fulfilled the inclusion criteria, 32.8% were female. In the female arm, the 24-month mortality for the groups with and without chronic total occlusion was similar (18.9% and 14.7%, respectively; p = 0.47). In contrast, in the male arm, the occurrence of chronic total occlusion was associated with higher 24-month mortality (24.3% vs. 13.4%; p = 0.009). Multivariate analysis of the male arm revealed a trend toward a positive association between the occurrence of chronic total occlusion and 24-month mortality (HR 1.62; 95% CI 0.93–2.83; p = 0.087). The presence of chronic total occlusion in men is associated with an adverse long-term prognosis, whereas in women this effect was not observed.


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