Research Papers: Gerotarget (Focus on Aging):

Serum uric acid level as a cardio-cerebrovascular event risk factor in middle-aged and non-obese Chinese men

Zhi-Jun Li _, Chen-Ju Yi, Jing Li and Na Tang

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Oncotarget. 2017; 8:24110-24118. https://doi.org/10.18632/oncotarget.15902

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Zhi-Jun Li1, Chen-Ju Yi1, Jing Li1 and Na Tang1

1 Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence to:

Zhi-Jun Li, email:

Keywords: serum uric acid, cardio-cerebrovascular events, middle-age, non-obese, Gerotarget 

Received: August 12, 2016 Accepted: February 21, 2017 Published: March 04, 2017


Aim: The role of uric acid as a risk factor for cardio-cerebrovascular diseases is controversial. In this study, we aimed to investigate the relationship between serum uric acid level and the risk of cardio-cerebrovascular events in middle-aged and non-obese Chinese men.

Methods: We included 3152 participants from the health examination center of Tongji Hospital from June 2007 to June 2010. Clinical examination and medical records were collected at the annual health examination. The hazard ratios (HRs) of uric acid for cardio-cerebrovascular events were calculated by Cox proportional hazards models. Generalized additive model and threshold effect analysis were used to explore the non-linear relationship between serum uric acid level and the incidence of cardio-cerebrovascular event.

Result: The mean follow-up time was 52 months. When the participants were classified into four groups by the serum acid quarter (Q1-Q4), the HRs (95% CI) of Q2-Q4 for cardio-cerebrovascular events were 1.26 (0.83, 1.92), 1.97 (1.33, 2.91) and 2.05 (1.40, 3.01), respectively, compared with the reference (Q1). The actual incidence and conditional incidence of cardio-cerebrovascular events in the high serum acid group were higher than those in the low serum acid group, which were stratified by the turning point (sUA = 372 μmol/L). We also showed a strong prognostic accuracy of the multiple variable-based score in 3 years and 5 years, with area under the receiver operating characteristic (ROC) curve of 0.790 (0.756-0.823) and 0.777 (0.749-0.804), respectively.

Conclusion: Serum uric acid level is a strong risk factor for cardio-cerebrovascular events.

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