MMP8 polymorphism is associated with susceptibility to osteonecrosis of the femoral head in a Chinese Han population
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Feimeng An1,2,*, Jieli Du2,*, Yuju Cao3, Jianping Shi4, Yongchang Guo3, Tianbo Jin5, Jian Li3, Junyu Chen1,2, Ping Li2, Mei Dong2, Guoqiang Wang2, Jianzhong Wang2
1Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
2Department of Orthopedics and Traumatology, The Second Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, China
3Zhengzhou TCM Traumatology Hospital, Zhengzhou, Henan, China
4Department of TCM Diagnosis, Inner Mongolia Medical University, Hohhot, China
5MOE Key Laboratory of Resource Biology and Modern Biotechnology, Northwest University, Xi’an, China
*These authors contributed equally to this work and should be considered co-first authors
Guoqiang Wang, email: [email protected]
Jianzhong Wang, email: [email protected]
Keywords: MMP8, single nucleotide polymorphisms, osteonecrosis of the femoral head, association study
Received: October 07, 2016 Accepted: January 09, 2017 Published: February 16, 2017
Osteonecrosis of the femoral head (ONFH) is an orthopedic refractory disease that adversely affects quality of life. Matrix metalloproteinase-8 (MMP-8) produced by the bone marrow has been implicated in the degradation of collagen during bone development. We assessed whether MMP8 polymorphisms are associated with ONFH. In a case-control study, using χ2 tests and genetic model analyses, we genotyped 5 MMP8 single-nucleotide polymorphisms (SNPs) in 585 ONFH patients and 507 healthy control subjects in a Chinese Han population. The MMP8 rs11225394 SNP was associated with an increased risk of ONFH in an allele model (OR=1.34; 95% CI, 1.003-1.786, P=0.047). In addition, rs11225394 was associated with an increased risk of ONFH in a dominant model (OR =1.39, 95% CI, 1.02–1.89, P=0.036), over-dominant model (OR=1.39, 95% CI, 1.02–1.89, P=0.038), and log-additive model (OR =1.36, 95% CI, 1.01–1.84, P=0.039). After adjusting for age and gender, rs11225394 was associated with ONFH in a dominant (OR =1.44, 95% CI, 1.05–1.96, P=0.023), over-dominant (OR =1.44, 95% CI, 1.05–1.98, P=0.022), and log-additive model (OR =1.40, 95% CI, 1.04–1.90, P=0.027). These results provide the first evidence that MMP8 SNP at the rs11225394 locus is associated with the increased risk of ONFH in Chinese Han population.
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