Research Papers:

Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis

Yang-Hua Fan, Miao-Jing Wu, Yuan Jiang, Minhua Ye, Shi-Gang Lu, Lei Wu and Xin-Gen Zhu _

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Oncotarget. 2017; 8:21410-21417. https://doi.org/10.18632/oncotarget.15247

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Yang-Hua Fan1,*, Miao-Jing Wu1,*, Yuan Jiang1, Minhua Ye1, Shi-Gang Lu1, Lei Wu1, Xin-Gen Zhu1

1Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, People’s Republic of China

*These authors have contributed equally to the work

Correspondence to:

Xin-Gen Zhu, email: [email protected]

Lei Wu, email: [email protected]

Keywords: HULC, neoplasm, metastasis, prognosis, meta-analysis

Received: September 09, 2016    Accepted: January 17, 2017    Published: February 10, 2017


Since the long non-coding RNA HULC (Highly Upregulated in Liver Cancer) is dysregulated in many cancers, we performed a meta-analysis to determine its prognostic potential in malignant tumors. We searched electronic databases, including PubMed, Medline, OVID, Cochrane Library and Web of Science from inception until August 14, 2016 and identified seven studies with 730 cancer patients for the meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between HULC expression and overall survival (OS). We also using RevMan5.3 software to calculate odds ratio (ORs) to assess the association between HULC expression and pathological parameters, including lymph node metastasis (LNM), distant metastasis (DM) and the tumor stage. Our analysis showed that higher HULC expression was associated with OS (HR= 0.50, 95% CI: 0.35–0.70, P <0.00001), LNM (OR=0.20, 95 % CI 0.06–0.64), DM (OR=0.27, 95% CI: 0.13–0.54) and the tumor stage (OR=0.39, 95 % CI 0.25–0.64). These meta-analysis data demonstrate that higher HULC expression can be a useful prognostic biomarker in human cancers.

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