Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis
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Zhen-Zhen Zhang1,2,*, Qiang Chen2,*, Chao-Yue Kong1, Zhan-Ming Li1, Li-Shun Wang1
1Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China
2School of Public Health Taishan Medical University, Shandong, P.R. China
*These authors have contributed equally to this work
Li-Shun Wang, email: firstname.lastname@example.org
Keywords: thyroid stimulating hormone receptor, thyroid cancer, diagnostic meta-analysis
Received: August 01, 2016 Accepted: December 12, 2016 Published: December 27, 2016
Thyroid stimulating hormone receptor messenger RNA (TSHR-mRNA) is over-expressed in thyroid cancer patients, which indicates that TSHR-mRNA is a potential biomarker of thyroid cancer. However, system evaluation for TSHR-mRNA as a diagnostic biomarker of thyroid cancer is deficient. The performance of TSHR-mRNA for thyroid cancer diagnosis was evaluated in this study. Three common international databases as well as a Chinese database were applied for literature researching. Quality assessment of the included literatures was conducted by the QUADAS-2 tool. Totally, 1027 patients from nine studies eligible for the meta-analysis were included in this study. Global sensitivity and specificity for the positivity of TSHR-mRNA in the thyroid cancer diagnosis is 72% and 82%. The value of AUC for this test performance was 0.84. Our meta-analysis suggests that TSHR-mRNA might be a potential biomarker to complete present diagnostic methods for early and precision diagnosis of thyroid cancer. Notably, this findings need validation thorough large-scale clinical studies.
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