Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis

Zhen-Zhen Zhang; Qiang Chen; Chao-Yue Kong; Zhan-Ming Li; Li-Shun Wang

doi:10.18632/oncotarget.14251

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis

Zhen-Zhen Zhang, Qiang Chen, Chao-Yue Kong, Zhan-Ming Li and Li-Shun Wang _

PDF | HTML | How to cite

Oncotarget. 2017; 8:6623-6629. https://doi.org/10.18632/oncotarget.14251

Metrics: PDF 2076 views | HTML 2563 views | ?

Abstract

Zhen-Zhen Zhang1,2,*, Qiang Chen2,*, Chao-Yue Kong1, Zhan-Ming Li1, Li-Shun Wang1

1Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China

2School of Public Health Taishan Medical University, Shandong, P.R. China

*These authors have contributed equally to this work

Correspondence to:

Li-Shun Wang, email: [email protected]

Keywords: thyroid stimulating hormone receptor, thyroid cancer, diagnostic meta-analysis

Received: August 01, 2016 Accepted: December 12, 2016 Published: December 27, 2016

ABSTRACT

Thyroid stimulating hormone receptor messenger RNA (TSHR-mRNA) is over-expressed in thyroid cancer patients, which indicates that TSHR-mRNA is a potential biomarker of thyroid cancer. However, system evaluation for TSHR-mRNA as a diagnostic biomarker of thyroid cancer is deficient. The performance of TSHR-mRNA for thyroid cancer diagnosis was evaluated in this study. Three common international databases as well as a Chinese database were applied for literature researching. Quality assessment of the included literatures was conducted by the QUADAS-2 tool. Totally, 1027 patients from nine studies eligible for the meta-analysis were included in this study. Global sensitivity and specificity for the positivity of TSHR-mRNA in the thyroid cancer diagnosis is 72% and 82%. The value of AUC for this test performance was 0.84. Our meta-analysis suggests that TSHR-mRNA might be a potential biomarker to complete present diagnostic methods for early and precision diagnosis of thyroid cancer. Notably, this findings need validation thorough large-scale clinical studies.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 14251

Publication Alerts

Research Papers:

Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis

Abstract