Research Papers:

Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis

Zhen-Zhen Zhang, Qiang Chen, Chao-Yue Kong, Zhan-Ming Li and Li-Shun Wang _

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Oncotarget. 2017; 8:6623-6629. https://doi.org/10.18632/oncotarget.14251

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Zhen-Zhen Zhang1,2,*, Qiang Chen2,*, Chao-Yue Kong1, Zhan-Ming Li1, Li-Shun Wang1

1Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China

2School of Public Health Taishan Medical University, Shandong, P.R. China

*These authors have contributed equally to this work

Correspondence to:

Li-Shun Wang, email: [email protected]

Keywords: thyroid stimulating hormone receptor, thyroid cancer, diagnostic meta-analysis

Received: August 01, 2016     Accepted: December 12, 2016     Published: December 27, 2016


Thyroid stimulating hormone receptor messenger RNA (TSHR-mRNA) is over-expressed in thyroid cancer patients, which indicates that TSHR-mRNA is a potential biomarker of thyroid cancer. However, system evaluation for TSHR-mRNA as a diagnostic biomarker of thyroid cancer is deficient. The performance of TSHR-mRNA for thyroid cancer diagnosis was evaluated in this study. Three common international databases as well as a Chinese database were applied for literature researching. Quality assessment of the included literatures was conducted by the QUADAS-2 tool. Totally, 1027 patients from nine studies eligible for the meta-analysis were included in this study. Global sensitivity and specificity for the positivity of TSHR-mRNA in the thyroid cancer diagnosis is 72% and 82%. The value of AUC for this test performance was 0.84. Our meta-analysis suggests that TSHR-mRNA might be a potential biomarker to complete present diagnostic methods for early and precision diagnosis of thyroid cancer. Notably, this findings need validation thorough large-scale clinical studies.

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