Research Papers:

Methicillin-resistant Staphylococcus aureus isolates in a hospital of Shanghai

Xiaoguang Wang, Lin Ouyang, Lingfei Luo, Jiqian Liu, Chiping Song, Cuizhen Li, Hongjing Yan and Ping Wang _

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Oncotarget. 2017; 8:6079-6084. https://doi.org/10.18632/oncotarget.14036

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Xiaoguang Wang1, Lin Ouyang1, Lingfei Luo1, Jiqian Liu1, Chiping Song1, Cuizhen Li1, Hongjing Yan1, Ping Wang1

1The Center for Disease Control and Prevention of Minghang District, Minghang District, Shanghai 201101, P.R. China

Correspondence to:

Ping Wang, email: [email protected]

Keywords: methicillin-resistant staphylococcus aureus (MRSA), hospital-associated MRSA, mecA gene, panton-valentine leukocidin (PVL) gene

Received: November 01, 2016     Accepted: December 13, 2016     Published: December 20, 2016


Methicillin-resistant Staphylococcus aureus (MRSA) strains are now common both in the health care setting and in the community. Active surveillance is critical for MRSA control and prevention. Specimens of patients (200 patients with 1119 specimens) as well as medical staff and hospital setting (1000 specimens) were randomly sampled in a level 2 hospital in Shanghai from September 2011 to August 2012. Isolation, cultivation and identification of S. aureus were performed. Totally, 67 S. aureus strains were isolated. 32 S. aureus strains were isolated from patient samples; 13 (13/32, 40.6%) of the 32 S. aureus isolates were MRSA; sputum sample and patients in the department of general internal medicine were the most frequent specimen and patient group for S. aureus strains isolation. Remaining 35 S. aureus strains were isolated from the medical staff and hospital setting; 20 (20/35, 57.1%) of the 35 S. aureus isolates were MRSA; specimens sampled from doctors and nurses’ hands and nose and hospital facilities were the most frequent samples to isolate S. aureus. Resistant and virulent genes detection showed that, all 33 MRSA strains were mecA positive which accounts for 49.3% of the 67 S. aureus strains; 38 isolates were Panton-Valentine leukocidin (PVL) gene positive which accounts for 56.7% of the 67 S. aureus strains; and 17 (17/67, 25.4%) isolates are mecA and PVL genes dual positive. Multidrug-resistant strains of MRSA and PVL positive S. aureus are common in patients, medical staff and hospital setting, the potential health threat is worthy of our attention.

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