Association of polymorphisms in the telomere-related gene ACYP2 with lung cancer risk in the Chinese Han population
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Nanzheng Chen1,*, Xiaomei Yang2,*, Wen Guo3, Jiangtao You1, Qifei Wu1, Guangjian Zhang1, Haijun Li1, Donghong Geng4, Tianbo Jin5, Junke Fu1, Yong Zhang1
1Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China
2Hospital 521 of China’s Ordnance Industry Group, Xi’an 710065, Shaanxi, China
3Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China
4School of Continuing Education of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, China
5School of Life Sciences, Northwest University, Xi’an 710069, Shaanxi, China
*These authors have contributed equally to this work
Junke Fu, email: [email protected]
Yong Zhang, email: [email protected]
Keywords: association study, lung cancer, telomere-related gene, single nucleotide polymorphisms (SNPs)
Received: August 26, 2016 Accepted: October 14, 2016 Published: December 10, 2016
Single nucleotide polymorphisms (SNPs) in the telomere-associated gene ACYP2 are associated with increased lung cancer risk. We explored the correlation between ACYP2 SNPs and lung cancer susceptibility in the Chinese Han population. A total of 554 lung cancer patients and 603 healthy controls were included in this study. Thirteen SNPs in ACYP2 were selected. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used assess the correlation between SNPs and lung cancer. We found that rs1682111 was associated with increased lung cancer risk in the recessive model (crude, OR=1.50, 95%CI: 1.04-2.16, p=0.029; adjusted for age, OR=1.55, 95%CI: 1.04-2.30, p=0.029), as was rs11896604 in the codominant model (crude, OR=0.65, 95%CI: 0.33-1.28, p=0.045; adjusted for age, OR=0.74, 95%CI: 0.36-1.53, p=0.049) and over-dominant model (crude, OR=1.30, 95%CI: 1.02-1.66, p=0.032; adjusted for age, OR=1.37, 95%CI: 1.05-1.78, p=0.020). Finally, rs843720 was associated with increased lung cancer risk in the recessive model (crude, OR=1.43, 95%CI: 1.02-2.02, p=0.040; adjusted for age, OR=1.48, 95%CI: 1.02-2.15, p=0.040). Thus three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population.
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