Oncotarget

Reviews:

LncRNAs: the bridge linking RNA and colorectal cancer

Yanfei Yang _, Linjie Zhao, Lingzi Lei, Wayne Bond Lau, Bonnie Lau, Qilian Yang, Xiaobing Le, Huiliang Yang, Chenlu Wang, Zhongyue Luo, Yu Xuan, Yi Chen, Xiangbing Deng, Lian Xu, Min Feng, Tao Yi, Xia Zhao, Yuquan Wei and Shengtao Zhou

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Oncotarget. 2017; 8:12517-12532. https://doi.org/10.18632/oncotarget.13573

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Abstract

Yanfei Yang1,*, Linjie Zhao1,*, Lingzi Lei1,*, Wayne Bond Lau2,*, Bonnie Lau3,*, Qilian Yang1, Xiaobing Le1, Huiliang Yang4, Chenlu Wang5, Zhongyue Luo5, Yu Xuan1, Yi Chen6, Xiangbing Deng6, Lian Xu7, Min Feng7, Tao Yi1, Xia Zhao1,Yuquan Wei1, Shengtao Zhou1

1Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital and State Key Laboratory of Biotherapy/Collaborative Innovation Center, West China Hospital, Sichuan University, Chengdu, P. R. China

2Department of Emergency Medicine, Thomas Jefferson University Hospital, U.S.A

3Department of Emergency Medicine, Kaiser Permanente Santa Clara Medical Center, Affiliate of Stanford University, U.S.A

4Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, P. R. China

5College of Life Sciences, Sichuan University, Chengdu, P. R. China

6Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China

7Department of Pathology, West China Second Hospital, Sichuan University, Chengdu, P. R. China

*These authors have contributed equally to this work

Correspondence to:

Shengtao Zhou, email: [email protected]

Keywords: lncRNAs, colorectal cancer, proliferation, angiogenesis, metastasis

Received: May 20, 2016    Accepted: November 12, 2016    Published: November 24, 2016

ABSTRACT

Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control pleiotropic cancer phenotypes through interactions with other cellular molecules including DNA, protein, and RNA. Recent studies have demonstrated that dysregulation of lncRNAs is influential in proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability in colorectal cancer (CRC), with consequent clinical implications. In this review, we explicate the roles of different lncRNAs in CRC, and the potential implications for their clinical application.


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