Research Papers:

Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas

Yang Zhao, Peng Xu, Huafeng Kang, Shuai Lin, Meng Wang, Pengtao Yang, Cong Dai, Xinghan Liu, Kang Liu, Yi Zheng and Zhijun Dai _

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Oncotarget. 2016; 7:86573-86583. https://doi.org/10.18632/oncotarget.13472

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Yang Zhao1,*, Peng Xu1,*, Huafeng Kang1, Shuai Lin1, Meng Wang1, Pengtao Yang1, Cong Dai1, Xinghan Liu1, Kang Liu1, Yi Zheng1, Zhijun Dai1

1Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, PR China

*These authors contributed equally to this work and share joint first authorship

Correspondence to:

Zhijun Dai, email: [email protected]

Keywords: prognostic nutritional index, digestive system carcinomas, prognosis, meta-analysis

Received: June 16, 2016     Accepted: November 08, 2016     Published: November 19, 2016


The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95% Confidence Interval (CI) 1.62–2.07], the poorer disease-free survival (DFS) (HR 1.85, 95% CI 1.19–2.89), and the higher rate of post-operative complications (HR 2.31, 95% CI 1.63–3.28). In conclusion, PNI was allowed to function as an efficient indicator for the prognosis of patients with digestive system carcinomas.

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