Genetic variants in the ZNF208 gene are associated with esophageal cancer in a Chinese Han population
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Huijie Wang1, Jianzhong Yu2, Yanling Guo1, Zhengxing Zhang1, Guoqi Liu1, Jingjie Li3, Xiyang Zhang4, Tianbo Jin3, Zhaoxia Wang1
1Department of Intergrated Traditional Chinese and Western Medicine in Oncology, Affiliated Luoyang Central Hospital, Zhengzhou University, Luoyang 471000, China
2Department of Neurology, Haikou People’s Hospital, Haikou 570208, Hainan, China
3Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China
4Xi’an Tiangen Precision Medical Institute, Xi’an, Shaanxi 710075, China
Zhaoxia Wang, email: [email protected]
Keywords: ZNF208, esophageal cancer, single nucleotide polymorphisms (SNPs), association study
Received: July 05, 2016 Accepted: October 29, 2016 Published: November 19, 2016
Previous studies showed an association between the ZNF208 gene and gastric cancer. In this study, we investigated the association between single nucleotide polymorphisms (SNPs) in ZNF208 and the risk of esophageal cancer in a Chinese Han population. We conducted a case-control study that included 386 cases and 495 controls. Five SNPs were selected from previous genome-wide association studies and genotyped using the Sequenom MassARRAY platform. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals after adjustment for age and gender. Logistic regressionl analysis showed that two SNPs (rs8103163 and rs7248488) were associated with an increased risk of esophageal cancer under different inheritance models after Bonferroni correction. Haplotype analysis suggested that the four variants comprised one block, and that the Grs2188972Crs2188971Crs8103163Crs7248488 haplotype was significantly correlated with an increased risk of esophageal cancer. Our data indicate that variants in ZNF208 are contribute to the susceptibility to esophageal cancer in a Chinese Han population.
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